ASO Author Reflections: Challenges of Circulating Tumor DNA in the Management of Gastrointestinal Peritoneal Carcinomatosis

Article Oncology

Circulating Tumor DNA is Unreliable to Detect Somatic Gene Alterations in Gastrointestinal Peritoneal Carcinomatosis

Brittany G. Sullivan et al.

Summary: This study found that peritoneal carcinomatosis (PC) is associated with lower levels of circulating tumor DNA (ctDNA) compared to other metastatic sites in gastrointestinal cancers. The researchers also caution that interpretation of ctDNA results in patients with PC should be done with caution due to lower sensitivity for detecting actionable mutations.

ANNALS OF SURGICAL ONCOLOGY (2023)

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Article Medicine, General & Internal

Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer

Jeanne Tie et al.

Summary: This study found that using ctDNA results to guide treatment decisions for stage II colon cancer reduced the use of adjuvant chemotherapy without compromising recurrence-free survival.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Oncology

Effects of Metastatic Sites on Circulating Tumor DNA in Patients With Metastatic Colorectal Cancer

Hideaki Bando et al.

Summary: The relationship between metastatic site and ctDNA detection was investigated in patients with limited-extent metastatic colorectal cancer (mCRC). The results showed that the metastatic site had an impact on ctDNA detection.

JCO PRECISION ONCOLOGY (2022)

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Article Oncology

Utility of tumor-informed circulating tumor DNA in the clinical management of gastrointestinal malignancies

Shannon Zhang et al.

Summary: This study utilized a personalized, tumor-informed ctDNA detection method in 198 GI cancer patients, showing that ctDNA positivity was significantly associated with advanced stage and presence/extent of metastases. Serial time-point analysis demonstrated successful clearance of ctDNA in a subset of patients following treatment.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

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Article Oncology