Journal
ANNALS OF SURGICAL ONCOLOGY
Volume 29, Issue 13, Pages 8198-8206Publisher
SPRINGER
DOI: 10.1245/s10434-022-12490-4
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Funding
- Juntendo University
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This study investigated the use of concurrent chemoradiotherapy followed by surgery for stage IIIA (N2) lung squamous cell carcinoma (LSCC). The results showed promising outcomes, with high 2-year progression-free survival and overall survival rates. The study suggests that this treatment approach is feasible for LSCC patients.
Background To date, no clinical trials on the use of induction therapy before surgery have focused solely on lung squamous cell carcinoma (LSCC). We report the results of the Personalized Induction Therapy-2 (PIT-2) trial, a multicenter phase II study, performed to investigate the efficacy and safety of S-1 + cisplatin with concurrent thoracic radiotherapy (TRT) followed by surgery in patients with stage IIIA (N2) LSCC. Methods Patients with pathologically proven stage IIIA (N2) LSCC received induction therapy comprising three cycles of S-1 + cisplatin with concurrent TRT (45 Gy in 25 fractions) followed by surgery. S-1 was administered orally at a dose of 40 mg/m(2) twice daily on days 1-14, in addition to intravenous infusion of cisplatin (60 mg/m(2)) on day 1. The primary endpoint was 2-year progression-free survival (PFS) rate. Results Of 45 registered patients, 43 underwent induction therapy. Of the 43 patients, 39 (91%) underwent surgery (35 lobectomies, 3 pneumonectomies, and 1 wedge resection). The 2-year PFS, 2-year overall survival, objective response rate, and pathological complete response rates were 67% (90% confidence interval [CI] 54-78%), 70% (95% CI 53-81%), 86% (95% CI 76-96%), and 39% (95% CI 23-54%), respectively. No new treatment-related adverse events occurred during the induction therapy. One case of 90-day postoperative mortality involving a patient who underwent right pneumonectomy and developed pneumonia after discharge occurred. Conclusions Induction therapy using S-1 + cisplatin with concurrent TRT followed by surgery is a feasible and promising treatment approach for stage IIIA (N2) LSCC.
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