Pulmonary hypertension mortality trends in United States 1999-2019

Purpose: Pulmonary hypertension (PH) is a heterogenous, often progressive disorder leading to right heart failure and death. Previous analyses show stable PH mortality rates from 1980 to 2001 but in-creasing from 2001 to 2010 especially among women and non-Hispanic (NH) Black. This study seeks to identify recent trends in PH mortality in the United States from 1999 to 2019.Methods: Mortality rates among individuals more than or equal to 15 years of age were obtained from the Centers for Disease Control and Prevention's (CDC) Wide-Ranging Online Data for Epidemiology Research (WONDER) database. ICD-10 codes were used to identify individuals with PH.Results: Between 1999 and 2019, PH was included as a cause on 429,105 recorded deaths. The average age-adjusted PH mortality rate was 7.9 per 10 0,0 0 0 individuals and increased by 1.9% per year. Higher age-adjusted mortality rates were experienced by females and NH Black persons. The crude mortality rate was 105.4 per 10 0,0 0 0 among those decedents 85 or older. From 1999 to 2019, mortality in PH and left heart disease co-occurrence increased at nearly double the annual rate of the overall PH group.Conclusions: Despite therapeutic advances for selected PH subgroups, the overall age-adjusted PH mortal-ity rate increased significantly from 1999 to 2019 and previously reported racial disparities have persisted. These findings emphasize the need for additional study to improve outcomes in PH.Published by Elsevier Inc.

Automated summary

This study examines recent trends in pulmonary hypertension (PH) mortality in the United States from 1999 to 2019. The findings show a significant increase in overall age-adjusted PH mortality rate during this period, with persistent racial disparities. The study highlights the need for further research to improve outcomes in PH.