Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 61, Issue 41, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202210043
Keywords
Fullerenes; Glycomimetic; Lectin; Multivalency; Peptides
Categories
Funding
- Spanish Agencia Estatal de Investigacion (AEI) [SAF2017-89890-R, PCI2019-103400, PID2020-117143RB-I00, PID2020-114653RB-I00, PID2020-115120GB-I00]
- Xunta de Galicia [ED431C 2017/25]
- Centro singular de investigacion de Galicia accreditation [ED431G 2019/03]
- European Commission (EC) (European Regional Development Fund-ERDF)
- ERC-STG (DYNAP) [677786]
- ERC-POC (TraffikGene) [838002]
- Xunta de Galicia (Oportunius Program)
- Human Frontier Science Programme Young Investigator Grant [RGY0066/2017]
- Spanish Ministerio de Universidades [BEAGAL18-00051]
- Comunidad de Madrid Atraccion de Talento program [2018-T2/BMD-10275]
- [ED481A-2018/116]
- [FPU17/00941]
- European Research Council (ERC) [838002, 677786] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Fully substituted peptide/[60]fullerene hexakis-adducts have the potential for multivalent protein recognition and offer synthetically simpler alternatives to natural ligands.
Fully substituted peptide/[60]fullerene hexakis-adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis-adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis-adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E-selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials.
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