Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 61, Issue 41, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202210019
Keywords
Antimony; Antitumor Agents; Antitumor Mechanism; Heterometallic Clusters; Polyoxometalates
Categories
Funding
- NNSFs of China [22171045, 92161108, 21971039]
- NSF of Fujian Province [2020J01438]
- Key Program of NSF of Fujian Province [2021J02007, 2021J06012]
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This study reports a giant Sb-rich polyoxometalate (POM) {Sb21Tb7W56}, which contains the largest number of Sb atoms in a POM. The Sb-rich POM exhibits broad-spectrum antitumor activity against various cancer cell lines and is capable of suppressing the growth and metastasis of a breast cancer in vivo.
Herein, a giant Sb-rich polyoxometalate (POM) {Sb21Tb7W56} is reported, which contains the largest number of Sb atoms in a POM so far. The Sb-rich POM has many interesting structural features and is a rare example of a soluble and water-stable giant POM. Biomedical studies indicate that the Sb-rich POM exhibits broad-spectrum antitumor activity against various cancer cell lines by reactivating the P53-dependent apoptotic processes and disrupting the mitochondrial membrane. In addition, this Sb-rich POM was capable of suppressing the growth and metastasis of a breast cancer in vivo. This work demonstrates that Sb-rich POMs are promising candidates for the development of new anticancer drugs.
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