Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 61, Issue 51, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202212873
Keywords
Ambident Nucleophile; Arylation; Bismuth; Density-Functional Calculations; Synthetic Methods
Categories
Funding
- Syngenta
- UKRI [MR/V022067/1]
- NSF [CHE-1955876]
- Frontera Fellowships Program (NSF) [1818253]
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This study demonstrates the utility of a modular, bismacycle-based system for the O-selective arylation of 2- and 4-pyridones with arylboronic acids. The research also shows that the kinetically-controlled regioselectivity for O-arylation is attributed to the geometric constraints imposed by the bismacyclic scaffold.
We report that O-selective arylation of 2- and 4-pyridones with arylboronic acids is affected by a modular, bismacycle-based system. The utility of this umpolung approach to pyridyl ethers, which is complementary to conventional methods based on SNAr or cross-coupling, is demonstrated through the concise synthesis of Ki6783 and picolinafen, and the formal synthesis of cabozantib and golvatinib. Computational investigations reveal that arylation proceeds in a concerted fashion via a 5-membered transition state. The kinetically-controlled regioselectivity for O-arylation-which is reversed relative to previous Bi-V-mediated pyridone arylations-is attributed primarily to the geometric constraints imposed by the bismacyclic scaffold.
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