4.2 Article

Defects in the expression of colonic host defense factors associate with barrier dysfunction induced by a high-fat/high-cholesterol diet

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Intestinal Cathelicidin Antimicrobial Peptide Shapes a Protective Neonatal Gut Microbiota Against Pancreatic Autoimmunity

Wenjie Liang et al.

Summary: This study identified a defective colonic expression of the CRAMP antimicrobial peptide as the cause of dysbiosis in newborn NOD mice, leading to pathological immune imprinting and the subsequent development of autoimmune diabetes in adulthood. Increasing colonic CRAMP expression can restore colonic homeostasis and prevent autoimmune diabetes.

GASTROENTEROLOGY (2022)

Article Microbiology

Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism

Jiafeng Xia et al.

Summary: Our study found that Akkermansia muciniphila attenuated APAP-induced liver injury by alleviating oxidative stress and inflammation in the liver, and its hepatoprotective effect was accompanied by activation of the PI3K/Akt pathway and mediated by regulation of the composition and metabolic function of the intestinal microbiota. This finding suggests that the microbial community has a significant impact on drug metabolism, and probiotic administration could be a potential therapy for drug-induced liver injury.

MICROBIOLOGY SPECTRUM (2022)

Article Multidisciplinary Sciences

The source of the fat significantly affects the results of high-fat diet intervention

Jiaxing An et al.

Summary: This study compared the effects of different sources of dietary fat on high-fat diet intervention and found that different types of dietary fat have significant effects on body and blood indicators in mice. The intervention of canola oil increased gut microbiota diversity, while the lard group showed the largest changes. The composition of saturated fatty acid (SFA) in fat had the most significant effects on the gut microbiome.

SCIENTIFIC REPORTS (2022)

Article Gastroenterology & Hepatology

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

Xiang Zhang et al.

Summary: High dietary cholesterol leads to sequential progression of steatosis, steatohepatitis, fibrosis and eventually HCC in mice, concomitant with insulin resistance. Cholesterol-induced NAFLD-HCC formation is associated with gut microbiota dysbiosis, with specific bacterial composition changes between stages of liver disease. Alterations in gut bacterial metabolites were also observed with dietary cholesterol intake. Therapies targeting cholesterol and gut microbiota may be effective for preventing NAFLD-HCC.
Article Cell Biology

Altered Mucus Barrier Integrity and Increased Susceptibility to Colitis in Mice upon Loss of Telocyte Bone Morphogenetic Protein Signalling

Vilcy Reyes Nicolas et al.

Summary: FoxL1(+)-Telocytes, originating from subepithelial in mice, play a crucial role in the pathogenesis of colonic neoplasia. Lack of BMP signalling in TCFoxL1+ leads to impaired mucosal structure, increased susceptibility to colitis, and delayed wound healing. These findings suggest the key roles of BMP signalling in TCFoxL1+ in the pathogenesis of IBD.

CELLS (2021)

Review Cell Biology

High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review

Ida Judyta Malesza et al.

Summary: The gut microbiota plays a crucial role in extracting energy from food, providing vitamins to the host, and acting as a barrier against exogenous pathogens. The Western diet, characterized by overeating, frequent snacking, and prolonged postprandial state, has been associated with dysbiosis and inflammation linked to excessive fat consumption.

CELLS (2021)

Article Cell Biology

Effect of a High-Fat Diet on the Small-Intestinal Environment and Mucosal Integrity in the Gut-Liver Axis

Takashi Nakanishi et al.

Summary: High-fat diet-induced dysbiosis in the small intestine leads to pathological changes in the luminal environment, disruption of small-intestinal mucosal integrity, and minimal inflammation in the gut-liver axis, ultimately resulting in the development of steatohepatitis in mice.

CELLS (2021)

Article Oncology

Alterations in Intestinal Microbiota Composition in Mice Treated With Vitamin D3 or Cathelicidin

Yu Jiang et al.

Summary: The study found that Vitamin D3 and Cathelicidin help maintain the balance of gut microbiota in mice by enhancing the colonization of bacterial taxa associated with protective effects to the host while repressing the propagation of bacterial taxa associated with harmful effects to the host. This effect involves various metabolic pathways related to amino acid and lipid metabolism.

FRONTIERS IN ONCOLOGY (2021)

Article Microbiology

Western-style diet impedes colonization and clearance of Citrobacter rodentium

Junqing An et al.

Summary: The Western-style diet high in fat and low in fiber can reduce gut microbiota density and colonization resistance, leading to difficulties in clearing pathogens and their virulence following infection. This dietary habit may also trigger persistent low-grade inflammation and insulin resistance.

PLOS PATHOGENS (2021)

Article Medicine, Research & Experimental

Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy

Zhengnan Ren et al.

Summary: This study found that defective production of CRAMP in gluten-induced enteropathy contributes to the development of celiac disease, while exogenous CRAMP can correct epithelial dysfunction and promote regulatory immune responses. Additionally, gut dysbiosis and the presence of Pseudomonas aeruginosa play a role in the defective intestinal CRAMP production.

EMBO MOLECULAR MEDICINE (2021)

Review Biochemistry & Molecular Biology

Neglected roles of IgG Fc-binding protein secreted from airway mucin-producing cells in protecting against SARS-CoV-2 infection

Kensuke Kobayashi et al.

Summary: The study discusses the roles of innate immunity and acquired immunity in SARS-CoV-2 infection, as well as the potential mechanism of Fc gamma bp in combating the pandemic.

INNATE IMMUNITY (2021)

Article Multidisciplinary Sciences

High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide

Woongjae Yoo et al.

Summary: It was found that chronic exposure to a high-fat diet can increase levels of circulating trimethlamine N-oxide, a potentially harmful metabolite generated by gut microbiota.

SCIENCE (2021)

Article Microbiology

High-Fat-Diet-Induced Oxidative Stress Linked to the Increased Colonization of Lactobacillus sakei in an Obese Population

Jee-Yon Lee et al.

Summary: The study found an increased abundance of Lactobacillus species in obese individuals, particularly Lactobacillus sakei, which was associated with high-fat diet and reactive oxygen species in feces. The L. sakei ob4.1 strain exhibited high catalase activity, aiding in colonization in the colon environment under high-fat diet-induced oxidative stress.

MICROBIOLOGY SPECTRUM (2021)

Review Gastroenterology & Hepatology

Mucins, gut microbiota, and postbiotics role in colorectal cancer

Ramesh Pothuraju et al.

Summary: An imbalance in the crosstalk between host and gut microbiota can lead to inflammatory diseases and colorectal cancer, with dietary patterns playing a crucial role in regulating gut microbiota composition and maintaining mucin expression. Proper communication between host and gut microbiota through different dietary patterns is essential for maintaining mucus composition and regulation in health and disease.

GUT MICROBES (2021)

Review Nutrition & Dietetics

Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review

Michael W. Rohr et al.

ADVANCES IN NUTRITION (2020)

Article Gastroenterology & Hepatology

High-Fat Diet Causes Constipation in Mice via Decreasing Colonic Mucus

Rieko Mukai et al.

DIGESTIVE DISEASES AND SCIENCES (2020)

Article Biochemistry & Molecular Biology

High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage

Shohei Tanaka et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Food Science & Technology

Plant- and Fish-Derived n-3 PUFAs Suppress Citrobacter Rodentium-Induced Colonic Inflammation

Pekka Maattanen et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2020)

Article Multidisciplinary Sciences

Trefoil factors share a lectin activity that defines their role in mucus

Michael A. Jarva et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Trefoil Factor Family (TFF) Peptides and Their Diverse Molecular Functions in Mucus Barrier Protection and More: Changing the Paradigm

Werner Hoffmann

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Regenerating islet-derived protein (Reg)3 beta plays a crucial role in attenuation of ileitis and colitis in mice

Ryodai Shindo et al.

BIOCHEMISTRY AND BIOPHYSICS REPORTS (2020)

Review Cell Biology

GI pros: Antimicrobial defense in the gastrointestinal tract

Lawton K. Chung et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

Article Neurosciences

High-fat diet causes psychiatric disorders in mice by increasing Proteobacteria population

Mi-Young Jeong et al.

NEUROSCIENCE LETTERS (2019)

Letter Biotechnology & Applied Microbiology

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

Evan Bolyen et al.

NATURE BIOTECHNOLOGY (2019)

Article Gastroenterology & Hepatology

High-fat diet promotes experimental colitis by inducing oxidative stress in the colon

Xue Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2019)

Review Microbiology

Citrobacter rodentium-host-microbiota interactions: immunity, bioenergetics and metabolism

Caroline Mullineaux-Sanders et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Article Biochemistry & Molecular Biology

Different Forms of TFF3 in the Human Saliva: Heterodimerization with IgG Fc Binding Protein (FCGBP)

Till Houben et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Gut-associated IgA+ immune cells regulate obesity-related insulin resistance

Helen Luck et al.

NATURE COMMUNICATIONS (2019)

Review Cardiac & Cardiovascular Systems

Dietary metabolism, the gut microbiome, and heart failure

W. H. Wilson Tang et al.

NATURE REVIEWS CARDIOLOGY (2019)

Review Gastroenterology & Hepatology

Frontline defenders: goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease

Joannie M. Allaire et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

Review Medicine, Research & Experimental

Altered Gut Microbiota: A Link Between Diet and the Metabolic Syndrome

Manuel T. Velasquez

METABOLIC SYNDROME AND RELATED DISORDERS (2018)

Review Immunology

Akkermansia muciniphila and its role in regulating host functions

Muriel Derrien et al.

MICROBIAL PATHOGENESIS (2017)

Editorial Material Immunology

Goblet cells as mucosal sentinels for immunity

M. A. McGuckin et al.

MUCOSAL IMMUNOLOGY (2017)

Article Nutrition & Dietetics

High- cholesterol diet does not alter gut microbiota composition in mice

Lidiya G. Dimova et al.

NUTRITION & METABOLISM (2017)

Article Multidisciplinary Sciences

Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium

Daniel C. Propheter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Gastroenterology & Hepatology

Western diets, gut dysbiosis, and metabolic diseases: Are they linked?

Kristina B. Martinez et al.

GUT MICROBES (2017)

Article Immunology

Dietary Lipid Type, Rather Than Total Number of Calories, Alters Outcomes of Enteric Infection in Mice

Daniella DeCoffe et al.

JOURNAL OF INFECTIOUS DISEASES (2016)

Article Biochemical Research Methods

DADA2: High-resolution sample inference from Illumina amplicon data

Benjamin J. Callahan et al.

NATURE METHODS (2016)

Article Multidisciplinary Sciences

High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine

Julie Tomas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22

Max Gulhane et al.

SCIENTIFIC REPORTS (2016)

Review Immunology

The immunology of host defence peptides: beyond antimicrobial activity

Robert E. W. Hancock et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Gastroenterology & Hepatology

Intestinal and neuronal myenteric adaptations in the small intestine induced by a high-fat diet in mice

Angelica Soares et al.

BMC GASTROENTEROLOGY (2015)

Article Microbiology

Quantitative Imaging of Gut Microbiota Spatial Organization

Kristen A. Earle et al.

CELL HOST & MICROBE (2015)

Review Biochemistry & Molecular Biology

The immunity-diet-microbiota axis in the development of metabolic syndrome

Eelke Brandsma et al.

CURRENT OPINION IN LIPIDOLOGY (2015)

Article Biochemistry & Molecular Biology

Autophagy Protects against Colitis by the Maintenance of Normal Gut Microflora and Secretion of Mucus

Koichiro Tsuboi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Veterinary Sciences

Up-Regulation of MUC2 Mucin Expression by Serum Amyloid A3 Protein in Mouse Colonic Epithelial Cells

Hiroaki Shigemura et al.

JOURNAL OF VETERINARY MEDICAL SCIENCE (2014)

Article Biochemistry & Molecular Biology

Ribosomal Database Project: data and tools for high throughput rRNA analysis

James R. Cole et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Multidisciplinary Sciences

AGR2, an Endoplasmic Reticulum Protein, Is Secreted into the Gastrointestinal Mucus

Joakim H. Bergstrom et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation

Fraenze Progatzky et al.

NATURE COMMUNICATIONS (2014)

Article Gastroenterology & Hepatology

Dietary oils modify the host immune response and colonic tissue damage following Citrobacter rodentium infection in mice

Azita Hekmatdoost et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Multidisciplinary Sciences

Distinct antimicrobial peptide expression determines host species-specific bacterial associations

Soeren Franzenburg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

Amandine Everard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Immunology

Intestinal antimicrobial peptides during homeostasis, infection, and disease

Luciana R. Muniz et al.

FRONTIERS IN IMMUNOLOGY (2012)

Article Biochemistry & Molecular Biology

A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ mice

Anne S. Henkel et al.

JOURNAL OF LIPID RESEARCH (2011)

Review Microbiology

Mucin dynamics and enteric pathogens

Michael A. McGuckin et al.

NATURE REVIEWS MICROBIOLOGY (2011)

Article Biotechnology & Applied Microbiology

Moving pictures of the human microbiome

J. Gregory Caporaso et al.

GENOME BIOLOGY (2011)

Article Gastroenterology & Hepatology

Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation

Claire Barbier de La Serre et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Article Endocrinology & Metabolism

Vitamin D Deficiency in Mice Impairs Colonic Antibacterial Activity and Predisposes to Colitis

Venu Lagishetty et al.

ENDOCRINOLOGY (2010)

Review Biochemistry & Molecular Biology

Gp-340/DMBT1 in mucosal innate immunity

Jens Madsen et al.

INNATE IMMUNITY (2010)

Article Immunology

Enteric defensins are essential regulators of intestinal microbial ecology

Nita H. Salzman et al.

NATURE IMMUNOLOGY (2010)

Article Hematology

Fish Oil Promotes Macrophage Reverse Cholesterol Transport in Mice

Tomoyuki Nishimoto et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Serum amyloid A induction of cytokines in monocytes/macrophages and lymphocytes

Changjie Song et al.

ATHEROSCLEROSIS (2009)

Article Gastroenterology & Hepatology

Colitis-Associated Variant of TLR2 Causes Impaired Mucosal Repair Because of TFF3 Deficiency

Daniel K. Podolsky et al.

GASTROENTEROLOGY (2009)

Article Gastroenterology & Hepatology

High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity

Marie A. Hildebrandt et al.

GASTROENTEROLOGY (2009)

Article Cell Biology

Diet-induced alterations in intestinal and extrahepatic lipid metabolism in liver fatty acid binding protein knockout mice

Elizabeth P. Newberry et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2009)

Article Multidisciplinary Sciences

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

Sung-Woo Park et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Gastroenterology & Hepatology

Diet-induced obesity and hepatic steatosis in L-Fabp(-/-) mice is abrogated with SF, but not PUFA, feeding and attenuated after cholesterol supplementation

Elizabeth P. Newberry et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

Article Biotechnology & Applied Microbiology

The mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract

Muriel Derrien et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2008)

Article Biochemistry & Molecular Biology

Biological and structural features of murine angiogenin-4, an angiogenic protein

Benedict Crabtree et al.

BIOCHEMISTRY (2007)

Article Allergy

Resistin-like molecule β regulates innate colonic function:: Barrier integrity and inflammation susceptibility

Simon P. Hogan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)

Article Gastroenterology & Hepatology

Liver fatty acid binding protein gene ablation potentiates hepatic cholesterol accumulation in cholesterol-fed female mice

GG Martin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

Review Cell Biology

Trefoil factors: Initiators of mucosal healing

D Taupin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Article Biochemistry & Molecular Biology

A new mathematical model for relative quantification in real-time RT-PCR

MW Pfaffl

NUCLEIC ACIDS RESEARCH (2001)

Article Endocrinology & Metabolism

Isolation and characterization of putative trefoil peptide receptors

L Thim et al.

REGULATORY PEPTIDES (2000)