4.8 Article

Quantitative High-Field NMR- and Mass Spectrometry-Based Fatty Acid Sequencing Reveals Internal Structure in Ru-Catalyzed Deuteration of Docosahexaenoic Acid

Related references

Note: Only part of the references are listed.
Article Cell Biology

Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload

Yingrui Liu et al.

Summary: Oxidative stress plays a central role in AMD, and DHA oxidation is central to the pathogenesis of iron-induced retinal degeneration. Deuterium-substituted DHA can prevent iron-induced retinal degeneration by inhibiting oxidative stress and lipid peroxidation.

AGING CELL (2022)

Article Chemistry, Analytical

Deep Structural Annotation of Glycerolipids by the Charge-Tagging Paterno-Buchi Reaction and Supercritical Fluid Chromatography-Ion Mobility Mass Spectrometry

Tian Xia et al.

Summary: Glycerolipids are crucial for cellular lipid homeostasis, with dysregulation in their metabolism linked to metabolic diseases. A new workflow utilizing charge-tagging PB derivatization, SFC, and MS/MS has been developed to accurately analyze GL structures and composition, potentially enabling lipid marker discovery for disease monitoring or diagnosis.

ANALYTICAL CHEMISTRY (2021)

Article Chemistry, Analytical

Toward Quantitative Sequencing of Deuteration of Unsaturated Hydrocarbon Chains in Fatty Acids

Dong Hao Wang et al.

Summary: This study introduces a novel method for quantitatively determining the deuterium content along a hydrocarbon chain. By utilizing deuteration reactions and analysis techniques, the method enables accurate quantification of deuterium abundance at different positions of D-HUFA.

ANALYTICAL CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Synthesis of deuterated γ-linolenic acid and application for biological studies: metabolic tuning and Raman imaging

Kosuke Dodo et al.

Summary: The study found that GLA itself exhibits tumor-selective cytotoxicity, independent of its oxidized metabolites. Deuteration of GLA can reduce toxicity towards normal cells and increase selectivity for tumor cells. Raman imaging confirmed the accumulation of fully deuterated GLA in intracellular lipid droplets of tumor cells.

CHEMICAL COMMUNICATIONS (2021)

Article Biochemical Research Methods

Fatty acid sentinels as covalently bound randomization standards for triacylglycerol (TAG) quantitative analysis

Dong Hao Wang et al.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2020)

Article Chemistry, Organic

Site-Specific Deuteration of Polyunsaturated Alkenes

A. V. Smarun et al.

JOURNAL OF ORGANIC CHEMISTRY (2017)

Article Chemistry, Analytical

Quantitative analysis of deuterium using the isotopic effect on quaternary 13C NMR chemical shifts

Tamim A. Darwish et al.

ANALYTICA CHIMICA ACTA (2016)

Article Multidisciplinary Sciences

Identification and quantitation of lipid C=C location isomers: A shotgun lipidomics approach enabled by photochemical reaction

Xiaoxiao Ma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Chemistry, Multidisciplinary

Full Library of (Bis-allyl)-deuterated Arachidonic Acids: Synthesis and Analytical Verification

Maksim A. Fomich et al.

CHEMISTRYSELECT (2016)

Article Biochemistry & Molecular Biology

Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress

Alexander Y. Andreyev et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Article Chemistry, Multidisciplinary

Pinpointing Double Bonds in Lipids by Paterno-Buchi Reactions and Mass Spectrometry

Xiaoxiao Ma et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Chemistry, Multidisciplinary

Unusual Kinetic Isotope Effects of Deuterium Reinforced Polyunsaturated Fatty Acids in Tocopherol-Mediated Free Radical Chain Oxidations

Connor R. Lamberson et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Biochemistry & Molecular Biology

Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation

Shauna Hill et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Biochemistry & Molecular Biology

Isotope-reinforced polyunsaturated fatty acids protect yeast cells from oxidative stress

Shauna Hill et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)