Journal
ANALYTICA CHIMICA ACTA
Volume 1234, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.aca.2022.340512
Keywords
Glycan enrichment; 2D nanomaterial; Nanotechnology; Glycomics
Categories
Funding
- Innovative Training Network [813120]
- Ministry of Health of the Slovak Republic [2019/7-CHUSAV-4, 2019/68-CHUSAV-1]
- Operational Program Integrated Infrastructure [ITMS: 313011V578]
- European Regional Development Fund [ITMS: 313011V578]
- Slovak Research and Development Agency [APVV-20-0272]
- Qatar University [QUCG-CAM-22/23-504]
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In this study, MXene was used as a column cartridge for N-glycan enrichment from human samples, with a focus on the analysis of sialic acid linkages. The MXene-based cartridge enriched a higher number of glycans compared to commercial HILIC columns. This study demonstrates the strong potential of MXene as a stationary phase in MS glycomic analysis.
In this study, we applied MXene as column cartridge for N-glycan enrichment from human samples with a focus on the analysis of sialic acid linkages using a derivatisation protocol followed by glycan analysis via Matrix Assisted Laser Desorption Ionisation-Time Of Flight Mass Spectrometry (MALDI-TOF-MS). The MXene-based cartridge enriches a higher number of glycans (i.e., sialylated and bisecting N-glycans) when compared to the commercial HILIC columns. We demonstrate the strong potential of MXene as a stationary phase in MS glycomic analysis.
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