Case Report: Cutaneous Leishmaniasis in a Rheumatoid Arthritis Patient Receiving Methotrexate

The immunosuppressive effect of methotrexate has rarely been associated with reactivation of cutaneous leishmaniasis. Here we present a case of a cutaneous leishmaniasis patient with atypical clinical symptoms without splenomegaly but with cutaneous manifestations after treatment of rheumatoid arthritis with methotrexate and blood recovery of the parasite. Next-generation sequencing was used to identify Leishmania infantum chagasi in the patient's blood sample.

Automated summary

We present a case of cutaneous leishmaniasis with atypical clinical symptoms in a patient receiving methotrexate treatment for rheumatoid arthritis, showing cutaneous manifestations and parasite recovery in blood using next-generation sequencing.