Inflammasome activation in preeclampsia and intrauterine growth restriction

Problem Preeclampsia (PE) and intrauterine growth restriction (IUGR) are leading causes of perinatal complications, affecting 8%-10% of all pregnancies. Inflammasomes are suspected to be one of the mechanisms that lead to the process of term and preterm labors. This study evaluated the inflammasome-dependent inflammation processes in placental tissue of women with PE and IUGR. Methods of Study In this prospective cohort study, 14 women with PE, 15 with placental-related IUGR and 19 with normal pregnancy (NP) were recruited during admission for delivery. Maternal blood was obtained prior to delivery and neonatal cord blood and placental tissue were obtained after delivery. Results NLRP7 and PYCARD protein expression were higher in placental PE and IUGR samples versus NP samples. Immunostaining revealed that NLRP7 and PYCARD were upregulated in PE and IUGR placental syncytiotrophoblast, stroma and endothelial cells. PYCARD serum levels were significantly higher in women with PE and IUGR. No significant changes were observed in neonatal cord blood. Conclusions NLRP7 and PYCARD are key inflammatory proteins that are significantly elevated in PE and IUGR. Better understanding their significance may enable them to become markers of prediction or progression of PE and IUGR.

Automated summary

This study evaluated the inflammasome-dependent inflammation processes in placental tissue of women with preeclampsia (PE) and intrauterine growth restriction (IUGR). The results showed that NLRP7 and PYCARD protein expression were significantly elevated in PE and IUGR placental samples. PYCARD serum levels were also significantly higher in women with PE and IUGR. These findings suggest that NLRP7 and PYCARD may serve as markers for predicting or monitoring the progression of PE and IUGR.