Journal
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Volume 323, Issue 4, Pages C1149-C1160Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00296.2022
Keywords
clinical targets HMGB1 protein; HMGB1 receptor; long noncoding RNA
Categories
Funding
- National Natural Science Foundation of China [81870802]
- Sichuan Science and Technology Program [2019YFS0356]
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This article systematically summarizes the lncRNAs related to HMGB1 and its essential receptors, highlighting the role of lncRNAs in upregulating HMGB1 and its receptors. It also explores the potential application prospects for the treatment of HMGB1-related disorders.
High-mobility group box 1 (HMGB1) not only induces cell proliferation and migration but also promotes cell apoptosis and autophagy. Abnormal expression of HMGB1 in plasma or body fluids could be detected in the occurrence and development of inflammation, cardiovascular disease, immune diseases, and cancer. In recent years, the accumulating research on lncRNAs had led us to the important role of lncRNAs in finely regulating the expression of molecules. Nevertheless, the roles of lncRNAs in upregulating HMGB1 and its receptors remain elusive. This article systematically summarizes the lncRNAs related to HMGB1 and its essential receptors such as RAGE. Multiple lncRNAs, such as lncRNA MALAT1 were proposed to regulate HMGB1 and its receptors upstream. As HMGB1-related diseases were summarized, we also expected predictable application prospects of both HMGB1 and related lncRNAs. The in- depth research focusing on lncRNAs behind HMGB1 and its receptors might provide a novel foundation for therapeutic treatment of HMGB1-related disorders, together with targets regarding HMGB1.
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