Twenty-Four-Hour Central Hemodynamic Load in Adults With and Without a History of COVID-19

BACKGROUND Although hypertension is a risk factor for severe Coronavirus Disease 2019 (COVID-19) illness, little is known about the effects of COVID-19 on blood pressure (BP). Central BP measures taken over a 24-hour period using ambulatory blood pressure monitoring (ABPM) adds prognostic value in assessing cardiovascular disease (CVD) risk compared with brachial BP measures from a single time point. We assessed CVD risk between adults with and without a history of COVID-19 via appraisal of 24-hour brachial and central hemodynamic load from ABPM. METHODS Cross-sectional analysis was performed on 32 adults who tested positive for COVID-19 (29 +/- 13 years, 22 females) and 43 controls (28 +/- 12 years, 26 females). Measures of 24-hour hemodynamic load included brachial and central systolic and diastolic BP, pulse pressure, augmentation index (AIx), pulse wave velocity (PWV), nocturnal BP dipping, the ambulatory arterial stiffness index (AASI), and the blood pressure variability ratio (BPVR). RESULTS Participants who tested positive for COVID-19 experienced 6 +/- 4 COVID-19 symptoms, were studied 122 +/- 123 days after testing positive, and had mild-to-moderate COVID-19 illness. The results from independent samples t-tests showed no significant differences in 24-hour, daytime, or nighttime measures of central or peripheral hemodynamic load across those with and without a history of COVID-19 (P > 0.05 for all). CONCLUSIONS No differences in 24-hour brachial or central ABPM measures were detected between adults recovering from mild-to-moderate COVID-19 and controls without a history of COVID-19. Adults recovering from mild-to-moderate COVID-19 do not have increased 24-hour central hemodynamic load.

Automated summary

Little is known about the effects of COVID-19 on blood pressure. This study compared the 24-hour hemodynamic load between adults recovering from mild-to-moderate COVID-19 and controls without a history of COVID-19. The results showed no differences in 24-hour brachial or central ambulatory blood pressure monitoring measures between the two groups.