4.2 Article Proceedings Paper

Clinical implications of asthma endotypes and phenotypes

Related references

Note: Only part of the references are listed.
Article Allergy

Paucigranulocytic asthma: Do sputum macrophages matter?

Muge Olgac et al.

Summary: Paucigranulocytic asthma (PGA) is the most common phenotype of stable asthma, characterized by predominant macrophages in sputum. PGA patients have a lower uncontrolled asthma ratio and lower FEV1 reversibility compared to other phenotypes.

ALLERGY AND ASTHMA PROCEEDINGS (2021)

Review Critical Care Medicine

Severe Adult Asthmas: Integrating Clinical Features, Biology, and Therapeutics to Improve Outcomes

Sally E. Wenzel

Summary: Evaluation and management of severe asthma remains a core focus in pulmonary practice. Advances in clinical phenotyping and molecular tools have greatly enhanced our understanding and treatment of severe asthma. Challenges still exist, but conceptual understanding of the disease has evolved significantly in a relatively short period of time.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Review Allergy

Switching between biologics in severe asthma patients. When the first choice is not proven to be the best

Andriana I. Papaioannou et al.

Summary: Biologic treatments have been introduced for asthma therapy, with individualized treatment choices posing challenges for physicians, leading to the need for constant adjustment and switching of medications.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

Review Allergy

Choice of biologics in asthma endotypes

Hannah Wangberg et al.

Summary: This study highlights the phenotypes and endotypes of asthma for selection of FDA approved biologic therapies. The evolving concept of asthma has led to identification of distinct phenotypes and endotypes. Biomarkers such as eosinophil count and specific IgE can predict response to biologic therapies for asthma.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Critical Care Medicine

Characteristics and Mechanisms of a Sphingolipid-associated Childhood Asthma Endotype

Daniela Rago et al.

Summary: This study explored a childhood asthma endotype characterized by reduced sphingolipid concentrations, early onset, and increased airway resistance. Lower concentrations of ceramides and sphingomyelins at 6 months correlated with an increased asthma risk before age 3, while reduced levels of key phosphosphingolipids at age 6 were associated with higher airway resistance. These associations were influenced by the 17q21 genotype and nasal gene expression of SPT.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Article Medicine, General & Internal

Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma

Michael E. Wechsler et al.

Summary: The study found that the monoclonal antibody itepekimab targeting interleukin-33 was more effective than placebo in improving lung function and reducing the incidence of loss of asthma control events in patients with moderate-to-severe asthma.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Risankizumab in Severe Asthma - A Phase 2a, Placebo-Controlled Trial

Christopher E. Brightling et al.

Summary: In a study involving adults with severe asthma, inhibition of interleukin-23 signaling with the monoclonal antibody risankizumab resulted in worse asthma outcomes than placebo.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Biochemistry & Molecular Biology

Tezepelumab: A Potential New Biological Therapy for Severe Refractory Asthma

Corrado Pelaia et al.

Summary: TSLP is an innate cytokine that plays a key role in asthma pathogenesis, while tezepelumab is a fully human monoclonal antibody that prevents TSLP's interaction with receptors. Preliminary results indicate that tezepelumab has a good safety and efficacy profile in patients with severe, uncontrolled asthma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, General & Internal

Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma

Andrew Menzies-Gow et al.

Summary: Tezepelumab, a monoclonal antibody targeting thymic stromal lymphopoietin, effectively reduces asthma exacerbations in patients with severe, uncontrolled asthma, leading to improved lung function, asthma control, and quality of life.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Genetics & Heredity

Biomarkers in Different Asthma Phenotypes

Sanja Popovic-Grle et al.

Summary: Asthma, the most common respiratory disease, has multiple phenotypes that can be differentiated by measuring specific biomarkers. Choosing suitable biomarkers to stratify patients remains a challenge, but the use of multiple biomarkers is superior for better disease evaluation.

GENES (2021)

Article Critical Care Medicine

Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial

Sarah Diver et al.

Summary: Tezepelumab demonstrates efficacy in reducing airway eosinophil counts and improving airway hyperresponsiveness in patients with severe uncontrolled asthma, regardless of baseline blood eosinophil count.

LANCET RESPIRATORY MEDICINE (2021)

Editorial Material Biochemistry & Molecular Biology

Metabolomics in the Identification of Biomarkers of Asthma

Alma Villasenor et al.

METABOLITES (2021)

Review Biochemistry & Molecular Biology

Monoclonal Antibodies Targeting Alarmins: A New Perspective for Biological Therapies of Severe Asthma

Corrado Pelaia et al.

Summary: Alarmins are innate cytokines, primarily produced by airway epithelium, playing a prominent role in asthma pathobiology. They are triggered by various environmental factors and serve as upstream activators of pro-inflammatory pathways, making them potential targets for severe asthma therapy.

BIOMEDICINES (2021)

Review Respiratory System

Identification and treatment of T2-low asthma in the era of biologics

Chris Kyriakopoulos et al.

Summary: The management of T2-low asthma remains a challenge due to poor response to steroids and limited candidates for targeted biologic agents. Current research is focused on identifying biomarkers for T2-low asthma and targeting neutrophilic airway inflammation as a therapeutic approach. Therapeutic targets include molecules that restore corticosteroid sensitivity, bronchodilators, anti-inflammatory agents, and airway smooth muscle mass attenuation therapies.

ERJ OPEN RESEARCH (2021)

Article Respiratory System

RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma

David Lamb et al.

Summary: ROR gamma t is a potential pharmacological target for severe asthma, with IL-17 and IL-22 being identified as important cytokines in the pathogenesis. The study showed that IL-17 and IL-22 both contribute to pro-inflammatory responses in lung cells and mice, with a ROR gamma t inhibitor blocking their effects and providing improved clinical benefit compared to blocking IL-17 alone.

RESPIRATORY RESEARCH (2021)

Article Respiratory System

Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

Fernando Holguin et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

Review Medicine, Research & Experimental

New Therapies for Emerging Endotypes of Asthma

Geoffrey Lowell Chupp et al.

ANNUAL REVIEW OF MEDICINE, VOL 71, 2020 (2020)

Review Physiology

ARE WE MEETING THE PROMISE OF ENDOTYPES AND PRECISION MEDICINE IN ASTHMA?

Anuradha Ray et al.

PHYSIOLOGICAL REVIEWS (2020)

Article Cardiac & Cardiovascular Systems

Obesity Phenotypes, Diabetes, and Cardiovascular Diseases

Marie-Eve Piche et al.

CIRCULATION RESEARCH (2020)

Review Allergy

T2-Low Asthma: Overview and Management Strategies

Anne M. Fitzpatrick et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

Article Allergy

Dupilumab Efficacy in Patients Stratified by Baseline Treatment Intensity and Lung Function

Ian D. Pavord et al.

JOURNAL OF ASTHMA AND ALLERGY (2020)

Review Immunology

Mechanisms of non-type 2 asthma

Stephanie N. Hudey et al.

CURRENT OPINION IN IMMUNOLOGY (2020)

Article Medicine, Research & Experimental

Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis

Lauren A. Henderson et al.

JCI INSIGHT (2020)

Review Allergy

Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease

Merin E. Kuruvilla et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2019)

Article Allergy

Anti-IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison

William Busse et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Article Allergy

Severe asthma-A population study perspective

Helena Backman et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2019)

Review Allergy

Does understanding endotypes translate to better asthma management options for all?

Adnan Custovic et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Article Critical Care Medicine

The Projected Economic and Health Burden of Uncontrolled Asthma in the United States

Mohsen Yaghoubi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Letter Allergy

Combination biologic therapy for severe persistent asthma

Gilbert Ortega et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2019)

Review Medicine, General & Internal

Viruses and non-allergen environmental triggers in asthma

Florence Chau-Etchepare et al.

JOURNAL OF INVESTIGATIVE MEDICINE (2019)

Article Allergy

Classification of asthma

Nurcicek Padem et al.

ALLERGY AND ASTHMA PROCEEDINGS (2019)

Review Allergy

Reslizumab Compared with Benralizumab in Patients with Eosinophilic Asthma: A Systematic Literature Review and Network Meta-Analysis

Thomas B. Casale et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

Review Immunology

Immunologic mechanisms in asthma

Tadech Boonpiyathad et al.

SEMINARS IN IMMUNOLOGY (2019)

Article Medicine, General & Internal

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

Klaus F. Rabe et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

M. Castro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Allergy

Use of biomarkers to identify phenotypes and endotypes of severe asthma

Tara F. Carr et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2018)

Review Allergy

Biologics and biomarkers for asthma, urticaria, and nasal polyposis

Thomas B. Casale

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Medicine, General & Internal

Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma

Parameswaran Nair et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Biochemistry & Molecular Biology

Emergence of Biomolecular Pathways to Define Novel Asthma Phenotypes Type-2 Immunity and Beyond

Sally E. Wenzel

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2016)

Editorial Material Allergy

Monitoring Allergic Patients on Omalizumab with Free and Total Serum IgE Measurements

Robert G. Hamilton

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2016)

Article Critical Care Medicine

Inflammation, Metabolic Dysregulation, and Pulmonary Function among Obese Urban Adolescents with Asthma

Deepa Rastogi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

Article Allergy

Risk of an asthma exacerbation after bariatric surgery in adults

Kohei Hasegawa et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

Article Allergy

IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers

Michelle L. Hernandez et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

Article Infectious Diseases

Global burden of asthma among children

I. Asher et al.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2014)

Article Allergy

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

Wendy C. Moore et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

Article Medicine, General & Internal

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

Elisabeth H. Bel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Critical Care Medicine

An Association between L-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype

Fernando Holguin et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

Article Critical Care Medicine

Exploring the Effects of Omalizumab in Allergic Asthma An Analysis of Biomarkers in the EXTRA Study

Nicola A. Hanania et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

Article Allergy

Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects

Annette T. Hastie et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Review Allergy

Untangling asthma phenotypes and endotypes

I. Agache et al.

ALLERGY (2012)

Article Multidisciplinary Sciences

Role of IL-1 Beta in the Development of Human TH17 Cells: Lesson from NLPR3 Mutated Patients

Denise Lasiglie et al.

PLOS ONE (2011)

Article Critical Care Medicine

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

Wendy C. Moore et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

Review Allergy

Food allergy and additives: triggers in asthma

JM Spergel et al.

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2005)