Journal
AGING-US
Volume 14, Issue 16, Pages 6642-6655Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.204236
Keywords
bladder cancer; drug resistance; Rhein; TRAIL; DR5
Categories
Funding
- Zhejiang TCM science and technology program [2020ZB217]
- Zhejiang Natural Science Fund [LY20H050002]
- Natural Science Fund [202003N4259]
- Zhejiang Provincial Foundation for Medical and Health Sciences [2019KY575]
- Fund of Ningbo Clinical Research Center for Urological Disease [2019A21001]
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This study found that the combination of rhein (RH) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can inhibit the proliferation and induce apoptosis of bladder cancer cells, suggesting its potential value in clinical treatment.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) combined with sensitizer is a potential method to reverse TRAIL-resistance in tumor cells. Rhein (RH) is a monomer extracted from Chinese herbs that has been reported to show anti-tumor effects in a variety of tumor cells, but the role of RH in TRAIL-induced anti-tumor effects in bladder cancer cells has not been reported. In this study, we found that the combined treatment of a non-toxic concentration of RH with TRAIL significantly inhibited the proliferation and induced apoptosis in both TRAIL sensitive and resistant bladder cancer cell lines. Furthermore, we found that RH promoted bladder cancer cell apoptosis by up-regulating DR5 expression. Our findings provide potential value in the clinical treatment of bladder cancer.
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