Cochlear Neurotrophin-3 overexpression at mid-life prevents age-related inner hair cell synaptopathy and slows age-related hearing loss

Article Chemistry, Multidisciplinary

Pharmacokinetics and biodistribution of supraparticle-delivered neurotrophin 3 in the guinea pig cochlea

Niliksha Gunewardene et al.

Summary: This study explored the potential of using supraparticles (SPs) to deliver neurotrophin-3 (NT3) to the inner ear and assessed the pharmacokinetics and biodistribution of SP-delivered NT3. The results showed that SPs can achieve sustained release and availability of neurotrophin in the inner ear.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Developmental Biology

Axon-glia interactions in the ascending auditory system

David C. Kohrman et al.

Summary: This review focuses on the roles of glial cells and glia-like cells in the ascending auditory pathway and their impact on the development, maintenance, and modulation of neural circuits and transmission in the auditory system. The molecular mechanisms of these interactions and their effects on auditory dysfunction associated with pathologies of each cell type are also discussed.

DEVELOPMENTAL NEUROBIOLOGY (2021)

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Article Chemistry, Multidisciplinary

An injectable PEG hydrogel controlling neurotrophin-3 release by affinity peptides

Jing Wang et al.

Summary: A study was conducted to develop an injectable hydrogel delivery system for localized release of neurotrophin-3, which provides affinity-controlled release and longer delivery time compared to Poloxamer hydrogels. The injectable PEG hydrogels induced local immune responses similar to biocompatible Poloxamer hydrogels, but released payloads at a slower rate. The sustained release of neurotrophin-3 from peptide-conjugated PEG hydrogels was verified, demonstrating a reversible interaction between peptides and proteins.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Neurosciences