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An Overview of Pituitary Neuroendocrine Tumors (PitNET) and Algorithmic Approach to Diagnosis

Journal

ADVANCES IN ANATOMIC PATHOLOGY
Volume 30, Issue 1, Pages 79-83

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PAP.0000000000000367

Keywords

pituitary neuroendocrine tumor (PitNET); transcription factors; somatostatin receptor analog; FIPA syndrome

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This article summarizes the evolution of the diagnostic algorithm and nomenclature of pituitary neuroendocrine tumors, highlighting a multimodal approach to their diagnosis and classification. It also provides brief comments on treatment and new guidelines for genetic screening, particularly for young patients.
The diagnostic algorithm and nomenclature of pituitary neuroendocrine tumors have evolved over the past decade, beginning with simpler categorical schemes focused on histomorphologic features and moving to a more sophisticated lineage-specific categorization. This contemporary overview highlights a multimodal approach to pituitary neuroendocrine tumors with a focus on changes in nomenclature, classification, and subclassification; including, brief comments on treatment, and new guidelines for genetic screening, particularly for young patients with such neoplasms.

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