Palladium-catalyzed Atroposelective Interannular C-H Arylation of Biaryl Aldehydes with Aryl Iodides Enabled by a Transient Directing Group Strategy

A concise synthesis of axially chiral biaryl aldehydes through Pd/amino acid-catalyzed atroposelective interannular C-H arylation of biaryl aldehydes with aryl iodides is developed. This reaction proceeds smoothly involving excellent enantiocontrol and accomplishes with good tolerance of functional groups. Moreover, the readily accessible scale-up synthesis and further transformation of products has highlighted the potential utility of this asymmetric catalytic protocol.

Automated summary

A concise method for the synthesis of axially chiral biaryl aldehydes has been developed through Pd/amino acid-catalyzed interannular C-H arylation of biaryl aldehydes with aryl iodides. This reaction exhibits excellent enantioselectivity and good tolerance towards functional groups. The scalability and potential utility of this asymmetric catalytic protocol have been highlighted.