4.8 Article

Direct Presentation of Tumor-Associated Antigens to Induce Adaptive Immunity by Personalized Dendritic Cell-Mimicking Nanovaccines

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Decade-long leukaemia remissions with persistence of CD4(+) CAR T cells

J. Joseph Melenhorst et al.

Summary: CAR T cells redirected to target CD19 demonstrated long-lasting potential and clonal stability in two patients with chronic lymphocytic leukaemia. Highly activated CD4(+) cells emerged and dominated the CAR T cell population at later time points. These unexpected CAR T cell populations provide novel insights into anti-cancer response and long-term remission in leukaemia.

NATURE (2022)

Article Multidisciplinary Sciences

GD2-CART cell therapy for H3K27M-mutated diffuse midline gliomas

Robbie G. Majzner et al.

Summary: Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are lethal pediatric tumors of the central nervous system. GD2-directed chimeric antigen receptor (CAR) T cells show promising preclinical efficacy. Four patients with H3K27M-mutated DIPG or spinal cord DMG were treated with GD2-CAR T cells and showed clinical and radiographic improvement.

NATURE (2022)

Article Multidisciplinary Sciences

Deciphering the immunopeptidome in vivo reveals new tumour antigens

Alex M. Jaeger et al.

Summary: This study engineered an inducible affinity tag into the mouse MHC-I gene to precisely isolate MHC-I peptides from autochthonous pancreatic ductal adenocarcinoma and lung adenocarcinoma in vivo. It revealed that peptide presentation in lung adenocarcinoma is not predictable by mRNA expression or translation efficiency and may be driven by post-translational mechanisms. Vaccination with peptides presented by lung adenocarcinoma induced CD8(+) T cell responses.

NATURE (2022)

Article Multidisciplinary Sciences

Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia

Han Dong et al.

Summary: Acute myeloid leukemia (AML) is difficult to treat due to a lack of tumor-specific targets for immune-based therapies. Recent studies have shown that natural killer (NK) cells exhibit innate memory and enhanced antitumor activity when activated with IL-12 and IL-18. This study demonstrates that arming CIML NK cells with a neoepitope-specific CAR significantly improves their antitumor responses to NPM1-mutated AML and avoids off-target toxicity.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Cell & Tissue Engineering

Cytokine Release Syndrome After Modified CAR-NK Therapy in an Advanced Non-small Cell Lung Cancer Patient: A Case Report

Xiaodi Zhang et al.

Summary: CAR-NK therapy has shown better efficacy and less toxicity in treating hematologic tumors, but cytokine release syndrome (CRS), a rare side effect, was observed in clinical trials. This report highlights the need to pay attention to CRS in NK cell therapy and suggests improvements to reduce potential toxicity.

CELL TRANSPLANTATION (2022)

Article Chemistry, Multidisciplinary

In Situ Transforming RNA Nanovaccines from Polyethylenimine Functionalized Graphene Oxide Hydrogel for Durable Cancer Immunotherapy

Yue Yin et al.

Summary: The research team developed a transformable hydrogel that can generate nanovaccines for up to 30 days after injection, showing promising potential for effective cancer immunotherapy.

NANO LETTERS (2021)

Article Multidisciplinary Sciences

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

Keman Cheng et al.

Summary: The study demonstrates a versatile OMV-based vaccine platform that can elicit a specific anti-tumor immune response by specifically presenting tumor antigens on the OMV surface. By employing a Plug-and-Display system, the engineered OMVs can simultaneously display multiple, distinct tumor antigens to promote a synergistic anti-tumor immune response.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19

Yue Yin et al.

Summary: The successful control of the COVID-19 pandemic relies not only on vaccine development, but also on efficient storage, transportation, and administration. Current nucleic acid vaccines stored frozen may face limitations in developing countries due to storage requirements. A separable microneedle patch has been developed to deliver vaccines intradermally, showing promising results in inducing strong and lasting immune responses compared to intramuscular injection.

ACS NANO (2021)

Article Cell Biology

Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

Long Chen et al.

Summary: Utilizing Escherichia coli cytoplasmic membranes as adjuvants, a vaccine based on hybrid membrane nanoparticles containing tumor cell membranes induced sufficient antitumor reactivity without notable adverse effects, showing efficacy in various tumor mouse models and providing long-term protection against tumor rechallenge.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Review Oncology

Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion

Suchit Jhunjhunwala et al.

Summary: This review discusses the importance of antigen presentation in the success of immune checkpoint inhibition therapy and mechanisms by which tumors evade immune recognition. Tumors evade immune recognition by modulating antigen expression and altering antigen presentation.

NATURE REVIEWS CANCER (2021)

Review Biotechnology & Applied Microbiology

NK cells for cancer immunotherapy

Noriko Shimasaki et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Multidisciplinary Sciences

MHC-II neoantigens shape tumour immunity and response to immunotherapy

Elise Alspach et al.

NATURE (2019)

Review Immunology

Engineering universal cells that evade immune detection

Robert Lanza et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Editorial Material Chemistry, Physical

Adoptive T cell cancer therapy

Karine N. Dzhandzhugazyan et al.

NATURE MATERIALS (2018)

Review Cell Biology

Dendritic cell-based immunotherapy

Rachel L. Sabado et al.

CELL RESEARCH (2017)

Article Multidisciplinary Sciences

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy

Kristin L. Griffiths et al.

NATURE COMMUNICATIONS (2016)

Article Oncology

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

Gregory L. Beatty et al.

CLINICAL CANCER RESEARCH (2015)

Review Immunology

Whole Tumor Antigen Vaccines: Where Are We?

Cheryl Lai-Lai Chiang et al.

VACCINES (2015)

Article Multidisciplinary Sciences

Structure-based programming of lymph-node targeting in molecular vaccines

Haipeng Liu et al.

NATURE (2014)

Article Multidisciplinary Sciences

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

Xiao-Dong Li et al.

SCIENCE (2013)

Article Chemistry, Multidisciplinary

Nanoparticles of Adaptive Supramolecular Networks Self-Assembled from Nucleotides and Lanthanide Ions

Ryuhei Nishiyabu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Review Immunology

Mechanisms and consequences of dendritic cell migration

David Alvarez et al.

IMMUNITY (2008)

Article Biochemistry & Molecular Biology

Therapeutic dendritic-cell vaccine for chronic HIV-1 infection

W Lu et al.

NATURE MEDICINE (2004)