A Universal Chemotactic Targeted Delivery Strategy for Inflammatory Diseases

Above 50% of deaths can be attributed to chronic inflammatory diseases; thus, the construction of drug delivery systems based on effective interaction of inflammatory factors with chemotactic nanoparticles is meaningful. Herein, a zwitterion-based artificial chemotactic nanomotor is proposed for universal precise targeting strategy in vivo, where the high level of reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) in inflammatory sites are used as a chemoattractant. Multidimensional static models, dynamic models, and in vivo models are established to evaluate chemotactic performance. The results show that the upregulated ROS and iNOS can induce the chemotaxis of nanomotors to diseased tissues in inflammation-related disease models. Further, mesoscale hydrodynamics simulations are performed to explain the chemotactic behavior of the nanomotors. Such a chemotactic delivery strategy is expected to improve delivery efficiency and may be applicable to a variety of inflammatory diseases.

Automated summary

A zwitterion-based artificial chemotactic nanomotor is proposed for precise targeting in vivo, utilizing high levels of reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) as chemoattractants. The chemotactic behavior of the nanomotors is evaluated through static models, dynamic models, in vivo models, and mesoscale hydrodynamics simulations. This chemotactic delivery strategy has the potential to improve delivery efficiency and be applicable to various inflammatory diseases.