A Photo-Responsive Hollow Manganese/Carbon Hybrid Nanosphere for Wound Disinfection and Healing

The emergence of multi-drug resistant (MDR) bacteria poses a serious threat to human health. It has become imperative to develop efficient antimicrobial strategies. Here, a manganese-doped dopamine-derived hollow carbon sphere (MnOx/HNCS) is developed as a nanozyme and photothermal agent for the synergistic treatment of MDR bacterial infections. MnOx/HNCS possesses oxidase, superoxide dismutase, and peroxidase like activities and implements self-cascading enzymatic catalysis to produce superoxide anion (O-2(center dot-)), hydrogen peroxide (H2O2), and hydroxyl radicals (center dot OH). Importantly, near-infrared light facilitates the electron transport of MnOx/HNCS, allowing it to exhibit stable photothermal effects and photo-enhanced enzymatic activity. Thereby MnOx/HNCS displays a broad-spectrum synergistic antibacterial efficiency in vitro against six MDR pathogens based on the above photo-regulated properties. In vivo experiments further demonstrate the excellent antibacterial efficiency of MnOx/HNCS in the MDR bacteria-infected wound model. Notably, MnOx/HNCS not only has excellent disinfection capacity, but also can accelerate wound healing by stimulating the deposition of the extracellular matrix and reepithelialization. This study proposes a promising antibiotics-alternative broad-spectrum antibacterial strategy and paves a new avenue for the establishment of multifunctional photo-responsive synergistic therapeutic platform.

Automated summary

In this study, a manganese-doped dopamine-derived hollow carbon sphere is developed as a nanozyme and photothermal agent for the synergistic treatment of multi-drug resistant bacterial infections. It exhibits multiple enzymatic activities and utilizes near-infrared light to enhance its catalytic and therapeutic effects, showing a broad-spectrum synergistic antibacterial efficiency against multi-drug resistant pathogens.