Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 32, Issue 52, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202208463
Keywords
bandgap modulations; lipid-intercalations; NIR-II excitations; phototheranostics; zwitterionic small molecules
Categories
Funding
- National Natural Science Foundation of China [21604042, 21674048]
- Natural Science Foundation of Jiangsu Province [BK20201380]
- Natural Science Foundation of Jiangsu Higher Education Institutions [20KJA430012]
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This study reports the development of a bright zwitterionic CSM nanoagent for tumor phototheranostics in the NIR-II region. The nanoagent exhibits high fluorescence quantum yield and excellent photothermal conversion efficiency, enabling precise and effective tumor treatment.
Conjugated small-molecule (CSM) phototheranostic agents that operate in the second near-infrared (NIR-II) region have garnered significant attention in the field of biomedicine. However, a lack of fluorescence-emitting ability hinders their use in precise fluorescence imaging (FI)-guided photothermal therapy (PTT). Herein, a two-pronged fluorescence intensification strategy-molecular engineering for rational bandgap modulation and lipid-intercalation to combat fluorescence quenching-is used to develop NIR-II-excited ultrabright donor-acceptor-donor-based (D-A-D)-based zwitterionic CSM nanoagent for tumor phototheranostics. The molecular engineering strategy produces the NIR-II-excited D-A-D-based zwitterionic fluorophore (BTFQ) that exhibits a high NIR-II fluorescence quantum yield (QY = 0.65%) in dichloromethane. More importantly, BTFQ complexed with liposome (DMPC) to form the zwitterion-liposome nanoagent (BTFQ/DMPC) shows a negligible loss of QY (0.63%) in aqueous media. Moreover, because BTFQ/DMPC possesses excellent photothermal conversion efficiency (PCE = 30.8%) performance, it can be used to realize efficient in vivo 1064 nm single-photon high-resolution NIR-II FI guided NIR-II PTT. This study introduces a new avenue for the development of NIR-II-excited NIR-II FI/PTT agents for precise and effective tumor treatment.
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