Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications

Layered double hydroxides (LDHs) are appealing nanomaterials for (bio)medical applications and their potential is threefold. One can gain advantage of the structure of LDH frame (i.e., layered morphology), anion exchanging property towards drugs with acidic character and tendency for facile surface modification with biopolymers. This review focuses on the third aspect, as it is necessary to evaluate the advantages of polymer adsorption on LDH surfaces. Beside the short discussion on fundamental and structural features of LDHs, LDH-biopolymer interactions will be classified in terms of the effect on the colloidal stability of the dispersions. Thereafter, an overview on the biocompatibility and biomedical applications of LDH-biopolymer composite materials will be given. Finally, the advances made in the field will be summarized and future research directions will be suggested. (c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Automated summary

Layered double hydroxides (LDHs) have great potential for (bio)medical applications due to their layered morphology, anion exchanging property, and facile surface modification with biopolymers. This review focuses on the advantages of polymer adsorption on LDH surfaces and its effect on the colloidal stability of dispersions. The biocompatibility and biomedical applications of LDH-biopolymer composite materials are discussed, and future research directions are suggested.