Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 190, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.addr.2022.114539
Keywords
Blood -brain barrier; Ultrasound contrast agents; Focused ultrasound; Cavitation; Drug delivery; Theranostics
Categories
Funding
- National Key R&D Program of China [2020YFA0908800]
- National Natural Science Foundation of China [81871376, 81660381]
- Guangdong Innovation Platform of Translational Research for Cerebrovascular Diseases
- Shenzhen Science and Technology Innovation Committee [JCYJ20190812171820731, JCYJ20170412171856582, JCYJ201805 07182420114]
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This review provides an overview of the basic mechanisms, medical applications, and evaluation methods of focused ultrasound combined with microbubbles for opening the blood-brain barrier (BBB), and discusses its potential in the treatment of glioblastoma, Alzheimer's disease, and Parkinson's disease.
Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases. Focused ultra-sound (FUS) combined with microbubbles (MBs) can locally and transiently open the BBB, providing a potential strategy for drug delivery across the BBB into the brain. Nowadays, taking advantage of this technology, many therapeutic agents, such as antibodies, growth factors, and nanomedicine formula-tions, are intensively investigated across the BBB into specific brain regions for the treatment of various brain diseases. Several preliminary clinical trials also have demonstrated its safety and good tolerance in patients. This review gives an overview of the basic mechanisms, ultrasound contrast agents, evaluation or monitoring methods, and medical applications of FUS-mediated BBB opening in glioblastoma, Alzheimer's disease, and Parkinson's disease.(c) 2022 Elsevier B.V. All rights reserved.
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