Journal
ADDICTION BIOLOGY
Volume 27, Issue 6, Pages -Publisher
WILEY
DOI: 10.1111/adb.13232
Keywords
alcohol brain damage; alcohol use disorder; biomarkers; neurofilament light chain; rats; tau protein
Categories
Funding
- Federation Hospitalo-Universitaire Network Of Research in Substance Use Disorders (FHU NOR-SUD) (Inserm/APHP/Universite Paris Cite) (intern call 2020)
- Inserm research unit UMRS-1144 Optimisation therapeutique en neuropsychopharmacologie (Inserm/Universite Paris Cite) (intern call 2020)
- FHU A2M2P Ameliorer le pronostic des troubles Addictifs et Mentaux par une Medecine Personnalisee
- ERA-NET programme: Psi-Alc [FKZ: 01EW1908]
Ask authors/readers for more resources
This translational study investigated the potential of plasma tau protein, neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCHL1) as predictive biomarkers of alcohol withdrawal-associated brain toxicity. The study found that NfL levels were higher in the alcohol cessation group and tau and UCHL1 levels were positively associated with diazepam dosage. In a preclinical study, NfL levels were higher in the alcohol deprivation effect (ADE) model. Plasma tau, NfL and UCHL1 show promise as biomarkers of brain suffering during alcohol withdrawal.
In this translational study, we investigated the plasma tau protein, neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCHL1), which are established biomarkers of neurological injury, as predictive biomarkers of alcohol withdrawal-associated brain toxicity. In the clinical study, patients with severe alcohol use disorder (AUD) on D1 of hospitalization for alcohol cessation (AC) (N = 36) were compared to severe AUD patients with at least 3 months of abstinence (N = 16). Overall, patients were 40 men (76.9%), aged 49.8 years [SD +/- 9.9]. Tau, NfL, GFAP and UCHL1 levels were measured using SIMOA and analysed with a quasipoisson regression model adjusted for age and sex. The NfL level was higher in the AC group (p = 0.013). In the AC group, the tau (p = 0.021) and UCHL1 (p = 0.021) levels were positively associated with the dose of diazepam per weight, and the tau (p = 0.045), NfL (p = 4.9 x 10(-3)) and UCHL1 (p = 0.036) levels were higher in the presence of signs of Wernicke's encephalopathy (n = 9). In the preclinical study, NfL and GFAP levels were assessed in the alcohol deprivation effect (ADE) procedure (N = 17) and control Wistar rats (N = 15). Furthermore, ADE rats were prospectively assessed: after 24 h (T1) and 3 weeks of AC (T2) (paired-samples Wilcoxon and Mann-Whitney tests). The NfL level was higher in the ADE model than in the control rats at both T1 and T2 (p = 0.033 and p = 1.3 x 10(-3)) and higher at T2 than at T1 (p = 0.040). Plasma tau, NfL and UCHL1 are potential biomarkers of brain suffering during alcohol withdrawal.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available