Journal
ACS NANO
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c05715
Keywords
sialic acid; lanthanide complexes; coordination polymer; luminescent sensing; cell migration
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Funding
- National Natural Science Foundation of China [21705165, 82073815]
- Open Project Program of MOE Key Laboratory of Drug Quality Control and Pharmaco vigilance [DQCP20/21MS03]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Double First-Class University Project [CPU2018GF07]
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In this study, a series of lanthanide-containing bimetallic complexes targeting Sialic acid were prepared. It was found that these complexes can be used for the detection of SA in blood samples, and they also showed potential for inhibiting tumor growth by targeting SA.
Sialic acid (SA) is overexpressed on cell membranes of tumor cells, and increased serum SA concentration has been observed in tumor-bearing patients. Herein, a series of lanthanide-containing bimetallic complexes (TDA-M-Lns) for targeting SA were prepared via coordination among luminescent lanthanide ions (Ln3+ = Tb3+, Eu3+, Dy3+, or Sm3+), metal ion quenchers (M2+ = Cu2+ or Co2+), and the organic ligand 2,2 '-thiodiacetic acid (TDA). SA can competitively coordinate with Ln3+, resulting in the signal-on of the Ln3+. Therefore, the TDA-M-Lns can be simply used for cost-saving detection of SA in the blood samples. Among the TDA-M-Lns, TDA-Co-Eu showed the highest sensitivity to detect SA in the blood of tumor-bearing mice. Furthermore, the TDA-Co-Eu was success-fully used to target SA and deposit Eu3+ on the surfaces of tumor cells for the inhibition of tumor cell growth and migration. The therapeutic effect of TDA-Co-Eu on a Balb/c mouse liver tumor model was evaluated. It was proved that TDA-Co-Eu can be applied for SA detection as well as for inhibiting tumor growth.
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