Journal
ACS NANO
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c05593
Keywords
active matter; collective motion; microtubules; persistence length; self-organization
Categories
Funding
- Japan Society for the Promotion of Science (JSPS) KAKENHI [17H03206, 20H00330]
- KEIRIN RACE
- Tateisi Science and Technology Foundation
- MEXT scholarship [171560]
- Kyoto University Nano Technology Hub in Nanotechnology Platform Project - MEXT, Japan
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Collective motion is a common phenomenon in nature, and it is mainly driven by dynamic collisions and alignments of cytoskeleton filaments. The study found that the persistence length of microtubules significantly affects their collective motion, with higher persistence leading to enhanced bundling. An agent-based computational model confirmed that the rigidity-dependent durability of microtubule alignment dominates their collective behavior.
Collective motion is a ubiquitous phenomenon in nature. The collective motion of cytoskeleton filaments results mainly from dynamic collisions and alignments; however, the detailed mechanism of pattern formation still needs to be clarified. In particular, the influence of persistence length, which is a measure of filament flexibility, on collective motion is still unclear and lacks experimental verifications although it is likely to directly affect the orientational flexibility of filaments. Here, we investigated the collective motion of microtubules with different persistence lengths using a microtubule-kinesin motility system. We showed that local interactions between microtubules significantly vary depending on their persistence length. We demonstrated that the bundling of microtubules is enhanced by more durable alignment, rather than by greater likelihood of alignment. An agent-based computational model confirmed that the rigidity-dependent durability of microtubule alignment dominates their collective behavior.
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