Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 39, Pages 44222-44227Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c13891
Keywords
sandwich-type immunosensor; electrochemiluminescence; N; B-Eu MOFs; high sensitivity; carcinoembryonic antigen
Funding
- National Natural Science Foundation of China
- Hunan Provincial Natural Science Foundation of China
- [22004032]
- [2021JJ20020]
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A novel sandwich-type immunosensor was developed using Pt@ SnS2 as a matrix and N,B-Eu MOFs as a signal amplifier. The immunosensor showed high sensitivity and selectivity for the detection of CEA. It exhibited excellent ECL performance and stability, making it suitable for real human serum.
Herein, a novel sandwich-type immunosensor was designed using Pt nanoparticle-decorated SnS2 nanoplates (Pt@ SnS2) as a matrix and N,B-doped Eu MOF (N,B-Eu MOF) nanospheres as a signal amplifier. In Pt@SnS2, Pt nanoparticles (NPs) enhance the surface electron transport capability and electrochemiluminescence (ECL) performance of SnS2 nanoplates. The dual antenna effect of 5-boronoisophthalic acid (5-bop) and 5-nitroisophthalic acid (5-nop) enables the N,B-Eu MOFs to show very good ECL performance at the cathode. In the presence of the target carcinoembryonic antigen (CEA), the sandwich-type immunosensor provides specific immune responses, and the ECL signal of the immunosensor is greatly amplified by the signal probe N,B-Eu MOFs. In view of the above, the immunosensor was successfully applied for highly sensitive and selective detection of CEA with a detection limit of 0.06 pg center dot mL-1. This sensor exhibits high sensitivity and specificity, excellent stability, good reproducibility, and good practicability in real human serum.
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