Journal
BMJ CASE REPORTS
Volume 15, Issue 7, Pages -Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/bcr-2021-247524
Keywords
Thrombotic Thrombocytopenic purpura; COVID-19; Vaccination; immunisation
Categories
Ask authors/readers for more resources
This study reports a case of relapsed immune thrombotic thrombocytopenic purpura (iTTP) in a patient who received Moderna mRNA-1273 SARS-CoV-2 vaccine and also developed severe COVID-19 infection. The authors summarize published cases of iTTP associated with COVID-19 infection or vaccination.
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease that may be triggered by inflammation, including infection or vaccination. Since the start of the COVID-19 pandemic, several case reports were published on de novo or relapsed immune TTP (iTTP) in COVID-19-infected patients. Case reports of iTTP episodes following vaccination against COVID-19 are also emerging. We report a case of relapsed iTTP in a patient who received Moderna mRNA-1273 SARS-CoV-2 vaccine and developed concurrent severe COVID-19 infection. The patient's iTTP was successfully managed with caplacizumab, therapeutic plasma exchange and high-dose steroids. We summarise published cases of iTTP associated with COVID-19 infection or vaccination.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available