Finding the best fit for improving reproducibility: reflections from the QUEST Center for Responsible Research

Article

Barriers to Full Participation in the Open Science Life Cycle among Early Career Researchers

Natasha J. Gownaris et al.

Data Science Journal (2022)

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Letter Biochemistry & Molecular Biology

Automated screening of COVID-19 preprints: can we help authors to improve transparency and reproducibility?

Tracey Weissgerber et al.

NATURE MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Improving target assessment in biomedical research: the GOT-IT recommendations

Christoph H. Emmerich et al.

Summary: Academic research plays a crucial role in identifying new drug targets, and this Perspective introduces a framework to assist academic scientists and funders in prioritizing target assessment activities to achieve scientific goals and objectives related to licensing, industry collaboration, and clinical trials.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Letter Multidisciplinary Sciences

Funders need to credit open science

Jim Falk

NATURE (2021)

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Editorial Material Biochemistry & Molecular Biology

Training early career researchers to use meta-research to improve science: A participant-guided learn by doing approach

Tracey L. Weissgerber

Summary: Meta-research, or the science of science, is a powerful technique that scientists can use to improve science. However, most scientists are unaware of its existence. This initiative demonstrates the feasibility of a participant-guided learn by doing approach through collaborating to design, conduct and publish a meta-research study.

PLOS BIOLOGY (2021)

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Article Biology

Investigating the replicability of preclinical cancer biology

Timothy M. Errington et al.

Summary: Replicability is an important feature of scientific research, but aspects of contemporary research culture, such as an emphasis on novelty, can make replicability seem less important than it should be. The Reproducibility Project: Cancer Biology aimed to provide evidence about the replicability of preclinical research in cancer biology by repeating selected experiments from high-impact papers. The study found that most of the original effects were positive effects, and in replication experiments, the effect sizes were generally smaller compared to the original experiments.

ELIFE (2021)

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Article Biology

Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology

Timothy M. Errington et al.

Summary: The study found that replicating preclinical research in cancer biology poses various challenges and barriers, such as lack of key data, insufficient experimental descriptions, and difficulties in obtaining author assistance, limiting the number of successful replications.

ELIFE (2021)

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Editorial Material Biology

Improving research quality: the view from the UK Reproducibility Network institutional leads for research improvement

Andrew J. Stewart et al.

Summary: The adoption and incentivisation of open and transparent research practices are essential for addressing issues related to research reproducibility and integrity. Both individuals and institutions need to be encouraged to prioritize research quality, with a focus on openness and transparency. Failure to do so may have negative consequences on UK-led innovation and commercialization.

BMC RESEARCH NOTES (2021)

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Article Biochemistry & Molecular Biology