Journal
ORAL SCIENCE INTERNATIONAL
Volume 20, Issue 1, Pages 60-64Publisher
WILEY
DOI: 10.1002/osi2.1147
Keywords
bone lesions; Langerhans cell histiocytosis; mandible; single-system multi-site; tumor
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The case report describes a 22-month-old boy with multiple-bone Langerhans cell histiocytosis (LCH). The patient presented with left cheek swelling, and imaging exams revealed bone resorption in the left mandibular angle. Further tests confirmed the diagnosis of LCH, and the patient underwent chemotherapy. After four years of treatment, the patient remains in good health without recurrence.
Background: Langerhans cell histiocytosis (LCH) is a rare disease in which antigen-presenting Langerhans cells proliferate abnormally. Case Presentation: We report a case of a 22-month-old boy who presented with left cheek swelling. A palpable bony bulge was noted at the left mandibular angle and a malignant tumor was suspected. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed an area of bone resorption from the left mandibular angle to the mandibular branch. Positron emission tomography (PET)-CT revealed accumulation in the left mandible, left femoral diaphysis, and L1 vertebra. The patient was diagnosed with multiple-bone LCH and underwent chemotherapy. Conclusion: Four years after treatment, the patient is doing well and has no recurrence.
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