Journal
CURRENT DEVELOPMENTS IN NUTRITION
Volume 6, Issue 8, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1093/cdn/nzac111
Keywords
vitamin K; cognition; chronic kidney disease; aging; matrix Gla protein
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [R01DK111392-S1, R01DK069406]
- USDA Agricultural Research Service [58-8050-9-004]
- NIDDK [U01DK060990, U01DK060984, U01DK061022, U01DK061021, U01DK061028, U01DK060980, U01DK060963, U01DK060902, U24DK060990]
- Perelman School of Medicine, University of Pennsylvania, Clinical and Translational Science Award
- National Institutes of Health/National Center for Advancing Translational Sciences (NIH/NCATS) [UL1TR000003]
- Johns Hopkins University [UL1 TR-000424]
- University of Maryland [GCRC M01 RR-16500]
- Clinical and Translational Science Collaborative of Cleveland from the NCATS component of the NIH [UL1TR000439]
- NIH Roadmap for Medical Research
- Michigan Institute for Clinical and Health Research [UL1TR000433]
- University of Illinois at Chicago [CTSA UL1RR029879]
- Tulane Center of Biomedical Research Excellence for Clinical and Translational Research in Cardiometabolic Diseases [P20 GM109036]
- Kaiser Permanente, NIH/National Center for Research Resources [UCSF-CTSI UL1 RR-024131]
- Department of Internal Medicine, School of Medicine, University of New Mexico [NM R01DK119199]
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This study found an association between vitamin K status and cognitive performance in individuals with chronic kidney disease. Participants with lower levels of plasma (dp)ucMGP, indicating higher vitamin K status, had better cognitive performance. Plasma phylloquinone levels were not significantly associated with cognitive performance. These findings suggest that vitamin K may play an important role in cognitive function in individuals with chronic kidney disease.
Vitamin K is linked to cognitive function, but studies in individuals with chronic kidney disease (CKD), who are at risk for vitamin K insufficiency and cognitive impairment, are lacking. The cross-sectional association of vitamin K status biomarkers with cognitive performance was evaluated in >= 55-y-old adults with CKD (N = 714, 49% female, 44% black). A composite score of a cognitive performance test battery, calculated by averaging the z scores of the individual tests, was the primary outcome. Vitamin K status was measured using plasma phylloquinone and dephospho-uncarboxylated matrix Gla protein [(dp)ucMGP]. Participants with low plasma (dp)ucMGP, reflecting higher vitamin K status, had better cognitive performance than those in the two higher (dp)ucMGP categories based on the composite outcome (P = 0.03), whereas it did not significantly differ according to plasma phylloquinone categories (P = 0.08). Neither biomarker was significantly associated with performance on individual tests (all P > 0.05). The importance of vitamin K to cognitive performance in adults with CKD remains to be clarified.
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