Effects of a Mindfulness-Based Weight Loss Intervention on Long-term Psychological Well-being Among Adults with Obesity: Secondary Analyses from the Supporting Health by Integrating Nutrition and Exercise (SHINE) Trial

Objectives This study tested whether a mindfulness-based intervention for obesity that included components aimed at emotion regulation and mindful eating improved psychological outcomes including stress, anxiety, positive emotion, and depression, during the intervention period and at longer-term follow-up. Methods Adults with obesity (N=194) were randomized to a 5.5-month diet-exercise weight loss intervention with or without mindfulness training focused on emotion regulation and mindful eating. Participants completed self-report measures of mindfulness and psychological well-being, which were planned secondary outcomes, at baseline, at mid-intervention (3 months), and at 6, 12, and 18 months post-baseline (maintenance period). Mixed effects models and linear regression were used to test between- and within-group changes in psychological well-being. This study also explored whether changes in mindfulness (from baseline to each 6 and 18 months post-baseline) mediated the effects of intervention arm on changes in psychological outcomes during those respective time periods. Finally, this study explored whether changes in mindfulness from baseline to 6 months mediated the effects of intervention arm on changes in psychological outcomes from baseline to 18 months. Results Participants randomized to the mindfulness arm had significant increases in positive emotions at all follow-up times compared to controls. There were statistically significant increases in mindfulness, psychological flexibility, and reflection, as well as decreases in anxiety and depressive symptoms at 12 months compared to control participants. These changes remained significant for psychological flexibility and reflection at 18 months. There were no significant differences in perceived stress. Among mindfulness participants, greater increases in mindfulness from 6 to 18 months were associated with greater positive emotions and psychological flexibility as well as lower perceived stress, anxiety, depressive symptoms, and rumination at 18 months, adjusting for 6-month values. Mediation analyses indicated that randomization to the mindfulness intervention arm was associated with 6-month increases in mindfulness, and these increases were in turn associated with improved psychological outcomes at 6 months and 18 months. Changes from baseline to 18 months did not mediate 18-month changes in psychological outcomes. Conclusions Mindfulness training in emotion regulation and mindful eating may provide greater longer-term psychological well-being benefits in non-clinical populations with obesity compared to conventional diet-exercise interventions.

Automated summary

This study examined the effects of a mindfulness-based intervention on psychological outcomes in individuals with obesity. The intervention included components focused on emotion regulation and mindful eating. The results showed that participants in the mindfulness group experienced significant improvements in positive emotions and reductions in anxiety and depressive symptoms compared to the control group. These improvements were maintained at the 18-month follow-up. Changes in mindfulness mediated the effects of the intervention on psychological outcomes at 6 and 18 months. The findings suggest that mindfulness training may have long-term benefits for psychological well-being in non-clinical populations with obesity.