2-methoxy-4-(((5-nitropyridin-2-yl)imino)methyl)phenol Schiff base ligand and its Cu(II) and Zn(II) complexes: synthesis, characterization and biological investigations

In this current work we have prepared a Schiff base ligand, (HL) derived from 5-nitropyridine-2-amine with 4-hy-droxy-3-methoxybenzaldehyde and its Cu(II), and Zn(II) in 2:1 stoichiometric ratio (2HL:M). The formation of the ligand and the metal complexes were evaluated by means of MS, FT-IR, UV-Visible, H-1-NMR, C-13-NMR and thermogravimetric methods. The free radical scavenging activity of compounds was evaluated through a sequence of in vitro assays viz., DPPH, ABTS and Superoxide where BHA was used as a positive controller. In vitro alpha-glucosidase inhibitory activities showed that complexes had considerable inhibitory potential when compared to the ligand.

Automated summary

In this study, a Schiff base ligand and its metal complexes were prepared and characterized by various analytical methods. The results showed that the metal complexes exhibited strong free radical scavenging activity and inhibitory potential against α-glucosidase.