Journal
FRONTIERS IN SURGERY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fsurg.2022.933781
Keywords
wound healing; stem cell; exosome; microRNA; long noncoding RNA; circular RNA; messenger RNA
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Funding
- special foundation of Guangzhou Key Laboratory [542 202002010004]
- Guangzhou Science and Technology Plan Project [202201020296]
- Guangdong Provincial Hospital of Chinese Medicine Science and Technology Research Program [2022KT1032, YN2019MJ11]
- scientific research project of Guangdong Administration of Traditional Chinese Medicine [20211315, 20222082]
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This article provides an overview of the role of stem cell-derived exosomal transcriptomes in wound healing, focusing on inflammation, angiogenesis, and scar formation.
Wound healing is a complex and integrated process of the interaction of various components within the injured tissue. Accumulating evidence suggested that stem cell-derived exosomal transcriptomes could serve as key regulatory molecules in wound healing in stem cell therapy. Stem cell-derived exosomal transcriptomes mainly consist of long noncoding RNAs (lncRNAs), microRNAs (miRNAs), circular RNAs (circRNAs) and messenger RNAs (mRNAs). In this article we presented a brief introduction on the wound repair process and exosomal transcriptomes. Meanwhile, we summarized our current knowledge of the involvement of exosomal transcriptomes in physiological and pathological wound repair process including inflammation, angiogenesis, and scar formation.
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