Journal
MEMBRANES
Volume 12, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/membranes12060633
Keywords
ESCRT; membrane scission; reverse topology; nuclear envelope; lysosome; membrane sealing; membrane repair
Categories
Funding
- Ministerio de Ciencia, Innovacion y Universidades (MCIU) [PGC2018-094164-A-I00, RYC-2017-22539]
- Agencia Estatal de Investigacion (AEI) [PGC2018-094164-A-I00, RYC-2017-22539]
- Fondo Europeo de Desarrollo Regional (FEDER) [PGC2018-094164-A-I00, RYC-2017-22539]
Ask authors/readers for more resources
This article reviews the molecular mechanisms of membrane constriction and scission by ESCRT-III and describes its essential role in sealing and repairing damaged cellular membranes.
The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III, together with the AAA ATPase VPS4, harbors the main remodeling and scission function of the ESCRT machinery, whereas early-acting ESCRTs mainly contribute to protein sorting and ESCRT-III recruitment through association with upstream targeting factors. Here, we review recent advances in our understanding of the molecular mechanisms that underlie membrane constriction and scission by ESCRT-III and describe the involvement of this machinery in the sealing and repairing of damaged cellular membranes, a key function to preserve cellular viability and organellar function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
