Journal
CHEMOSENSORS
Volume 10, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/chemosensors10070234
Keywords
lateral flow; saliva; COVID-19; IgG; SARS-CoV-2; gold nanoparticles
Funding
- Natural Sciences and Engineering Research Council (NSERC)
- CFI
- BCKDF
- University of Victoria, Department of Chemistry
- NSERC [550059-29, 2020-04236]
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A rapid lateral flow screening tool using saliva samples and cell phone quantification has been developed, providing sensitive detection of IgG antibodies against SARS-CoV-2 within 10 minutes.
Although several biomedical assays have been developed to screen for antibodies against SARS-CoV-2, very few can be completed without drawing blood. We developed a rapid lateral flow screening tool that used saliva samples and yielded rapid results that could be quantified using a cell phone. This assay provided the sensitive detection of IgG antibodies against SARS-CoV-2 within 10 min. We started by synthesising, modifying, and characterising gold nanoparticles. Using these particles as a coloured label, we developed a lateral flow strip made of nitrocellulose, glass fibre, and cellulose material. We quantified our visual results using pictures acquired with a cell phone and calculated a limit of detection of 4 ng/mL of antibodies against the SARS-CoV-2 spike protein.
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