Journal
BIOSENSORS-BASEL
Volume 12, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/bios12080594
Keywords
photoacoustic imaging; contrast agent; wavelength; spectroscopic analysis; contrast-enhanced imaging
Funding
- Korean government: the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2021R1A5A1032937, 2021R1F1A1062224]
- Korea Health Industry Development Institute (KHIDI) - Ministry of Health and Welfare [HI18C2383]
- National Research Foundation of Korea [2021R1F1A1062224] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This review focuses on various contrast agents used in photoacoustic imaging, including organic dyes, polymeric nanoparticles, gold nanoparticles, and other inorganic nanoparticles. By exploring the light absorption ranges of these agents, researchers are provided with insights and developments in contrast agents for photoacoustic imaging.
Photoacoustic imaging using endogenous chromophores as a contrast has been widely applied in biomedical studies owing to its functional imaging capability at the molecular level. Various exogenous contrast agents have also been investigated for use in contrast-enhanced imaging and functional analyses. This review focuses on contrast agents, particularly in the wavelength range, for use in photoacoustic imaging. The basic principles of photoacoustic imaging regarding light absorption and acoustic release are introduced, and the optical characteristics of tissues are summarized according to the wavelength region. Various types of contrast agents, including organic dyes, semiconducting polymeric nanoparticles, gold nanoparticles, and other inorganic nanoparticles, are explored in terms of their light absorption range in the near-infrared region. An overview of the contrast-enhancing capacity and other functional characteristics of each agent is provided to help researchers gain insights into the development of contrast agents in photoacoustic imaging.
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