4.6 Article

Effects of Aroclor 1254 on Intestinal Immunity, Metabolism, and Microflora in Zebrafish

Journal

FRONTIERS IN NUTRITION
Volume 9, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fnut.2022.929925

Keywords

microbiome; PCBs (polychlorinated biphenyls); gut; metabolomics; zebrafish

Funding

  1. Marine Economic Development Project of Guangdong Province Special Fund for Promoting High-quality Economic Development [GDOE2019A52]
  2. Guangdong Postgraduate Education Innovation Project [2020SFJD001]
  3. International Science and Technology Cooperation Project of Guangdong Province [2016A050502062]

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This experiment evaluated the effects of PCB exposure on the intestines of zebrafish. The results showed that PCBs exposure led to intestinal inflammation and oxidative stress in zebrafish, while also disturbing intestinal metabolites and microbiota, highlighting the consequences of PCB exposure.
Polychlorinated biphenyls (PCBs) are widely distributed environmental toxicants, whose biological toxicity is magnified step by step through the transmission of the food chain. However, there is little research about the effect of PCBs on intestinal epithelial barrier function. In this experiment, the effects of PCB exposure on the intestines of zebrafish were evaluated. Animals were exposed to Aroclor 1254 (5 mu g/L, 10 mu g/L, 15 mu g/L). After 21 days, the changes in histology, enzyme biomarkers, intestinal microorganisms, and metabolomics were detected. The inflammation and oxidative stress in the intestines of zebrafish were observed. Additionally, there were significant changes in intestinal microbiota and tissue metabolism, most of which were associated with oxidative stress, inflammation, and lipid metabolism. The results showed that PCBs exposure resulted in intestinal inflammation and oxidative stress in zebrafish.Moreover, intestinal metabolites and intestinal microflora of zebrafish were also disturbed. This study verified that exposure can lead to intestinal damage and changes in intestinal metabolic capacity and microorganisms, enlightening the consequences of PCB exposure.

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