Journal
FRONTIERS IN NUTRITION
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnut.2022.961182
Keywords
Chuanmingshen violacenm; polysaccharide; antioxidant activity; myocardial ischemia-reperfusion; ferroptosis
Categories
Funding
- China Postdoctoral Science Foundation [2020T130334]
- Shandong Traditional Chinese Medicine Science and Technology Project [2021M137]
- Macao Science and Technology Development Fund [FDCT 007/2020/ALC]
- Shenzhen-Hong Kong-Macau ST Program [SGDX2020110309420200]
- Research Fund of University of Macau [CPG2022-00005-ICMS]
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In this study, a novel polysaccharide, Chuanminshen violaceumis polysaccharide (CVP), was isolated from the root of Chuanminshen violaceum. The protective effect of CVP against myocardial ischemia-reperfusion injury was confirmed, and it was found to inhibit ferroptosis to ameliorate the injury.
We isolated and purified a novel polysaccharide from the root of Chuanminshen violaceum, namely, Chuanminshen violaceumis polysaccharide (CVP) and confirmed its structure and molecular weight. Furthermore, in vivo experiment, CVP's protective effect against myocardial ischemia-reperfusion (I/R) injury in mice was evidenced by significantly reducing I/R-induced myocardial infarction (MI) size, decreasing the secretion of heart damage biomarkers, and improving cardiac function. Then, the myocardial anoxia/reoxygenation (A/R) injury model was established to mimic reperfusion injury. Noticeably, ferroptosis was the major death manner for A/R-damaged H9c2 cells. Meanwhile, CVP significantly inhibited ferroptosis by decreasing intracellular Fe2+ level, enhancing GPX4 expression, and suppressing lipid peroxidation to confront A/R injury. In conclusion, CVP, with a clear structure, ameliorated I/R injury by inhibiting ferroptosis.
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