JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression

Review Cell Biology

Multiple functions of pyruvate kinase M2 in various cell types

Yoon-Beom Lee et al.

Summary: PKM2, a key metabolic enzyme, plays multiple roles in cells including traditional metabolic functions, transcriptional regulation, and protein kinase activity. Its posttranslational modifications can alter cellular functions. PKM2 is highly expressed in cancer cells, embryonic cells, and astrocytes, while mature neurons predominantly express PKM1.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Article Biochemistry & Molecular Biology

The deubiquitinase JOSD2 is a positive regulator of glucose metabolism

Lyudmila Krassikova et al.

Summary: The study identified the uncharacterized deubiquitinase JOSD2 as a positive regulator of cancer cell proliferation by controlling glucose catabolism enzymes. JOSD2 deficiency leads to cytostatic effects and decreased glycolysis in a broad spectrum of tumor cells, with its expression correlating with poor prognosis in non-small cell lung cancer.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Pharmacology & Pharmacy

Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression

Meijia Qian et al.

Summary: Cholangiocarcinoma (CCA) is a challenging cancer with limited treatment options. The study discovered the crucial role of JOSD2 in regulating YAP/TAZ protein stability, inhibiting CCA proliferation, and establishing a positive correlation between JOSD2 and YAP abundance in CCA patients. This research suggests JOSD2 as a potential intervention target for YAP/TAZ-related CCA patients.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Oncology

Deubiquitinases in hematological malignancies

Hu Lei et al.

Summary: Recent studies have identified certain DUBs as promising therapeutic targets in hematological malignancies, with the development of potent inhibitors showing promising inhibitory efficacy. Different DUBs play distinct roles in various types of blood cancers, emphasizing the importance of exploring their biological functions for potential therapeutic targets.

BIOMARKER RESEARCH (2021)

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Review Pharmacology & Pharmacy