4.6 Article

Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs) Harboring Oncogenic Potential and Is Markedly Upregulated in Hepatocellular Carcinoma

Related references

Note: Only part of the references are listed.
Article Oncology

A novel immunodiagnosis panel for hepatocellular carcinoma based on bioinformatics and the autoantibody-antigen system

Jinyu Wu et al.

Summary: By screening autoantibodies and establishing a diagnostic model for hepatocellular carcinoma (HCC), the study demonstrated the effectiveness in diagnosing early HCC and potentially improving the diagnostic rate for AFP-negative patients. The diagnostic model could be a new approach for HCC diagnosis, especially for early-stage cases, showing promising results in combination with AFP.

CANCER SCIENCE (2022)

Article Oncology

Somatic mutation and expression of BAP1 in hepatocellular carcinoma: an indicator for ferroptosis and immune checkpoint inhibitor therapies

Yu-Chuan Yan et al.

Summary: This study suggests that high expression of BAP1 in HCC is associated with poor prognosis, immunosuppression, and ferroptosis. BAP1 may serve as a promising prognostic marker for HCC patients and a complementary indicator for specific therapies.

JOURNAL OF CANCER (2022)

Article Oncology

X-Linked Tumor Suppressor Genes Act as Presumed Contributors in the Sex Chromosome-Autosome Crosstalk in Cancers

Bhanupriya Dhabhai et al.

Summary: This discussion focuses on the relative contribution of X-linked human tumor suppressor genes in various cancer types, highlighting their involvement in breast cancer and prostate cancer, as well as the observed alterations in promoter methylation patterns linked to mutational burden.

CANCER INVESTIGATION (2022)

Article Oncology

Epigenetic Regulatory Enzymes: mutation Prevalence and Coexistence in Cancers

Amit Sharma et al.

Summary: Epigenetic regulation plays an important role in transcriptional control and can affect a broad spectrum of the genome. In various cancers, hundreds of novel driver genes have been identified due to recurrent mutations, with a focus on the contribution of DNA methylation and histone modifications to cancer phenotype. Studying somatic mutations related to epigenetics in early cellular differentiation stages may provide insights into their impact on the cancer genome later on.

CANCER INVESTIGATION (2021)

Editorial Material Oncology

30 years of CIK cell therapy: recapitulating the key breakthroughs and future perspective

Amit Sharma et al.

Summary: Emerging evidence from clinical trials suggests that optimizing CIK cell therapy in combination with other contemporary cancer therapies may be key in combating cancer.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Oncology

Long non-coding RNA MAPKAPK5-AS1/PLAGL2/HIF-1α signaling loop promotes hepatocellular carcinoma progression

Liang Wang et al.

Summary: MAPKAPK5-AS1 acts as an oncogene in HCC by upregulating PLAG1 like zinc finger 2 (PLAGL2) expression, acting as a ceRNA to sponge miR-154-5p, and activating EGFR/AKT signaling. Additionally, hypoxia-inducible factor 1 alpha (HIF-1 alpha) directly binds to MAPKAPK5-AS1 promoter, suggesting a hypoxia-mediated MAPKAPK5-AS1/PLAGL2/HIF-1 alpha signaling loop in HCC progression.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Biology

Immunoautophagy-Related Long Noncoding RNA (IAR-lncRNA) Signature Predicts Survival in Hepatocellular Carcinoma

Yulu Wang et al.

Summary: The immuno-autophagy-related long non-coding RNA (IARlncRNA) signature established in this study demonstrates prognostic ability in hepatocellular carcinoma, with potential clinical implications. This study represents the first attempt to combine immune, autophagy, and long non-coding RNAs as determinants in HCC, necessitating further molecular validation in clinical samples.

BIOLOGY-BASEL (2021)

Review Oncology

Immunotherapy for Hepatocellular Carcinoma: Current Limits and Prospects

Cheng Zhong et al.

Summary: This review summarizes immune tolerance and immunotherapeutic strategies for hepatocellular carcinoma (HCC), as well as the main challenges of current therapeutic approaches, and presents alternative strategies for overcoming these limitations.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/β-Catenin Signaling

Cong Xu et al.

Summary: ATE1 plays a critical role in growth and malignancy of liver cancer, with reduced expression associated with poor clinical outcomes in HCC patients. Knockdown of ATE1 promotes liver cancer growth and migration.

MOLECULAR CANCER RESEARCH (2021)

Review Gastroenterology & Hepatology

Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma

Fang Wang et al.

Summary: This review summarizes the new proto-oncogenes and tumor suppressor genes identified in hepatocellular carcinoma (HCC) over the past five years, which may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients.

LIVER RESEARCH (2021)

Article Biochemistry & Molecular Biology

Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration

Amit Sharma et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

The lncRNA MIR4435-2HG is upregulated in hepatocellular carcinoma and promotes cancer cell proliferation by upregulating miRNA-487a

Qinglei Kong et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2019)

Review Medicine, General & Internal

Hepatocellular Carcinoma

Augusto Villanueva

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, Research & Experimental

Regulator of G protein signaling 20 promotes proliferation and migration in bladder cancer via NF-κB signaling

Gang Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Biochemistry & Molecular Biology

Emerging Roles of G Protein-Coupled Receptors in Hepatocellular Carcinoma

Wen-Ting Peng et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Regulator of G protein signaling 20 correlates with clinicopathological features and prognosis in triple-negative breast cancer

Quan Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Biochemical Research Methods

Predicting RNA-Protein Interactions Using Only Sequence Information

Usha K. Muppirala et al.

BMC BIOINFORMATICS (2011)

Article Biochemistry & Molecular Biology

RGS16 Inhibits Breast Cancer Cell Growth by Mitigating Phosphatidylinositol 3-Kinase Signaling

Genqing Liang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)