4.6 Review

Junctional Adhesion Molecules: Potential Proteins in Atherosclerosis

Journal

FRONTIERS IN CARDIOVASCULAR MEDICINE
Volume 9, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2022.888818

Keywords

junctional adhesion molecules; atherosclerosis; inflammation; thrombosis; transendothelial migration

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This review summarizes the roles of JAMs in the development of atherosclerosis and predicts future research directions.
Junctional adhesion molecules (JAMs) are cell-cell adhesion molecules of the immunoglobulin superfamily and are involved in the regulation of diverse atherosclerosis-related processes such as endothelial barrier maintenance, leucocytes transendothelial migration, and angiogenesis. To combine and further broaden related results, this review concluded the recent progress in the roles of JAMs and predicted future studies of JAMs in the development of atherosclerosis.

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