4.7 Article

Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression

Related references

Note: Only part of the references are listed.
Review Genetics & Heredity

Deconstructing Sonic Hedgehog Medulloblastoma: Molecular Subtypes, Drivers, and Beyond

Jesus Garcia-Lopez et al.

Summary: Medulloblastoma is a highly malignant cerebellar tumor predominantly diagnosed during childhood. The SHH-MB subtype, driven by pathogenic activation of the Sonic Hedgehog signaling pathway, accounts for nearly one-third of diagnoses. Extensive molecular analyses have identified intertumoral heterogeneity among SHH-MB tumors, prompting the recognition of novel subtypes.

TRENDS IN GENETICS (2021)

Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

Article Biotechnology & Applied Microbiology

Multiplex digital spatial profiling of proteins and RNA in fixed tissue

Christopher R. Merritt et al.

NATURE BIOTECHNOLOGY (2020)

Article Biochemical Research Methods

ProTrack: An Interactive Multi-Omics Data Browser for Proteogenomic Studies

Anna Pamela Calinawan et al.

PROTEOMICS (2020)

Article Multidisciplinary Sciences

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate

Jamie Zagozewski et al.

NATURE COMMUNICATIONS (2020)

Article Oncology

Response to trametinib treatment in progressive pediatric low-grade glioma patients

Florian Selt et al.

JOURNAL OF NEURO-ONCOLOGY (2020)

Article Biochemistry & Molecular Biology

Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer

Francesca Petralia et al.

Article Oncology

IL6/STAT3 axis mediates resistance to BRAF inhibitors in thyroid carcinoma cells

Tiziana Notarangelo et al.

CANCER LETTERS (2018)

Article Biochemical Research Methods

XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data

Roelof J. C. Kluin et al.

BMC BIOINFORMATICS (2018)

Article Biochemical Research Methods

Salmon provides fast and bias-aware quantification of transcript expression

Rob Patro et al.

NATURE METHODS (2017)

Letter Medicine, General & Internal

Selumetinib in Plexiform Neurofibromas

Jose S. Pulido et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Oncology

Intertumoral Heterogeneity within Medulloblastoma Subgroups

Florence M. G. Cavalli et al.

CANCER CELL (2017)

Article Clinical Neurology

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus

Vijay Ramaswamy et al.

ACTA NEUROPATHOLOGICA (2016)

Article Biochemical Research Methods

Combenefit: an interactive platform for the analysis and visualization of drug combinations

Giovanni Y. Di Veroli et al.

BIOINFORMATICS (2016)

Article Oncology

Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma

Daniel Markowitz et al.

MOLECULAR CANCER THERAPEUTICS (2016)

Article Biochemical Research Methods

Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown

Mihaela Pertea et al.

NATURE PROTOCOLS (2016)

Article Medicine, General & Internal

Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas

Eva Dombi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Neurosciences

Characterization of Cancer Stem Cells and Primary Cilia in Medulloblastoma

David Gate et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2015)

Article Biochemistry & Molecular Biology

Isolation and characterization of cancer stem cells from medulloblastoma

J. Liu et al.

GENETICS AND MOLECULAR RESEARCH (2015)

Article Biochemistry & Molecular Biology

The Molecular Signatures Database Hallmark Gene Set Collection

Arthur Liberzon et al.

CELL SYSTEMS (2015)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Oncology

Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma

Nataliya Zhukova et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

Article Dermatology

Stat3-Targeted Therapies Overcome the Acquired Resistance to Vemurafenib in Melanomas

Fang Liu et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

Article Clinical Neurology

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

Paul A. Northcott et al.

ACTA NEUROPATHOLOGICA (2012)

Article Clinical Neurology

Molecular subgroups of medulloblastoma: the current consensus

Michael D. Taylor et al.

ACTA NEUROPATHOLOGICA (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Biochemical Research Methods

Molecular signatures database (MSigDB) 3.0

Arthur Liberzon et al.

BIOINFORMATICS (2011)

Article Oncology

STAT3 Mediates Resistance to MEK Inhibitor through MicroRNA miR-17

Bingbing Dai et al.

CANCER RESEARCH (2011)

Article Oncology

Medulloblastoma Comprises Four Distinct Molecular Variants

Paul A. Northcott et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

Article Oncology

Therapeutic Potential of AZD1480 for the Treatment of Human Glioblastoma

Braden C. McFarland et al.

MOLECULAR CANCER THERAPEUTICS (2011)

Article Multidisciplinary Sciences

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

Robert L. Yauch et al.

SCIENCE (2009)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Identification of human brain tumour initiating cells

SK Singh et al.

NATURE (2004)