4.7 Article

Genome-Wide Association Study Identifies Multiple Susceptibility Loci for Malignant Neoplasms of the Brain in Taiwan

Journal

JOURNAL OF PERSONALIZED MEDICINE
Volume 12, Issue 7, Pages -

Publisher

MDPI
DOI: 10.3390/jpm12071161

Keywords

brain cancer; glioma; SNP; LMF1; RBFOX1

Funding

  1. Tri-Service General Hospital [TSGH-E111226]
  2. Ministry of Science and Technology [MOST 109-2314-B-016-016-MY2]

Ask authors/readers for more resources

The genetic susceptibility for primary brain malignancy differs between GBM and non-GBM tumors, potentially reflecting different etiologies. This study identified five new genes associated with malignant brain tumors and suggested that RNA modification may be related to major risk factors in primary malignant brain neoplasms.
Primary brain malignancy is a rare tumor with a global incidence of less than 10 per 100,000 people. Hence, there is limited power for identifying risk loci in individual studies, especially for Han Chinese. We performed a genome-wide association study (GWAS) in Taiwan, including 195 cases and 195 controls. We identified five new genes for malignant neoplasms of the brain: EDARADD (rs645507, 1p31.3, p = 7.71 x 10(-5), odds ratio (OR) = 1.893), RBFOX1 (rs8044700, p = 2.35 x 10(-5), OR = 2.36), LMF1 (rs3751667, p = 7.24 x 10(-7), OR = 2.17), DPP6 (rs67433368, p = 8.32 x 10(-5), OR = 3.94), and NDUFB9 (rs7827791, p = 9.73 x 10(-6), OR = 4.42). These data support that genetic susceptibility toward GBM or non-GBM tumors is highly distinct, likely reflecting different etiologies. Combined with signaling analysis, we found that RNA modification may be related to major risk factors in primary malignant neoplasms of the brain.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available