Journal
JOURNAL OF PERSONALIZED MEDICINE
Volume 12, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/jpm12081230
Keywords
grip strength; cognition; older adults; longitudinal study
Funding
- King's College London MRC Skills Development Fellowship programmed - UK Medical Research Council (MRC) [MR/R016372/1]
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London [S-BRC-1215-20018]
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- UK Medical Research Council
- Engineering and Physical Sciences Research Council
- Economic and Social Research Council
- Department of Health and Social Care (England)
- Chief Scientist Office of the Scottish Government Health and Social Care Directorates
- Health and Social Care Research and Development Division (Welsh Government)
- Public Health Agency (Northern Ireland)
- British Heart Foundation
- Welcome Trust
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
- Health Foundation
- Chilean National Fundfor Science and Technology (FONDECYT) grants [1080589, 1130947]
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Growing evidence suggests that early changes in physical functioning can serve as a potential biomarker for cognitive impairment. Our study provides robust evidence of the association between grip strength and cognitive performance, and explores how socioeconomic factors can impact this association and its variability across countries.
Growing evidence about the link between cognitive and physical decline suggests the early changes in physical functioning as a potential biomarker for cognitive impairment. Thus, we compared grip-strength trajectories over 12-16 years in three groups classified according to their cognitive status (two stable patterns, normal and impaired cognitive performance, and a declining pattern) in two representative UK and Chilean older adult samples. The samples consisted of 7069 UK (ELSA) and 1363 Chilean participants (ALEXANDROS). Linear Mixed models were performed. Adjustments included socio-demographics and health variables. The Declined and Impaired group had significantly lower grip-strength at baseline when compared to the Non-Impaired. In ELSA, the Declined and Impaired showed a faster decline in their grip strength compared to the Non-Impaired group but differences disappeared in the fully adjusted models. In ALEXANDROS, the differences were only found between the Declined and Non-Impaired and they were partially attenuated by covariates. Our study provides robust evidence of the association between grip strength and cognitive performance and how socio-economic factors might be key to understanding this association and their variability across countries. This has implications for future epidemiological research, as hand-grip strength measurements have the potential to be used as an indicator of cognitive performance.
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