4.7 Article

Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome

Ivayla Roberts et al.

Summary: This study utilizes untargeted metabolomics analysis to evaluate 120 samples of COVID-19 patients and predict the severity and outcome of the infection. The study identifies a group of metabolites with relevant biological functions, such as deoxycytidine and ureidopropionate (indirectly reflecting viral load), kynurenine (reflecting host inflammatory response), and multiple short chain acylcarnitines (energy metabolism) that can predict disease severity and outcome.

METABOLOMICS (2022)

Article Multidisciplinary Sciences

Metabolomics study of COVID-19 patients in four different clinical stages

Alberto Valdes et al.

Summary: This study aims to provide new information about the altered biomolecule profile and biological pathways in patients with SARS-CoV-2 infection. Metabolomics analysis of plasma samples from COVID-diagnosed patients revealed potential biomarkers for distinguishing between different clinical stages of the disease. The levels of these biomarkers normalized at hospital discharge, suggesting their potential as early prognosis biomarkers in COVID-19.

SCIENTIFIC REPORTS (2022)

Review Endocrinology & Metabolism

Switching Host Metabolism as an Approach to Dampen SARS-CoV-2 Infection

Sameh Soliman et al.

Summary: COVID-19 pandemic has altered daily lives worldwide, prompting the development of therapeutics and prophylactics to combat the viral infection. Recent recommendations highlight dietary modifications as a key approach post-lockdown. Changing host metabolism to a fat-dependent state, incorporating intermittent fasting, and supplementing with MCTs like lauric acid may hinder viral replication, serving as a potential prophylactic and adjunct therapy.

ANNALS OF NUTRITION AND METABOLISM (2021)

Article Biochemistry & Molecular Biology

Large-Scale Multi-omic Analysis of COVID-19 Severity

Katherine A. Overmyer et al.

Summary: The study conducted RNA-seq and high-resolution mass spectrometry on blood samples from COVID-19-positive and COVID-19-negative patients, identifying molecular features associated with disease severity and outcomes, offering pathophysiological insights and therapeutic suggestions. The observed dysregulation of platelet function, blood coagulation, acute phase response, and endotheliopathy further illuminated the unique COVID-19 phenotype. The findings are presented through a web-based tool enabling interactive exploration and machine learning prediction of COVID-19 severity.

CELL SYSTEMS (2021)

Article Medicine, General & Internal

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

A. C. Kalil et al.

Summary: Combination treatment with baricitinib plus remdesivir was superior to remdesivir alone in reducing recovery time and accelerating improvement in clinical status among patients with Covid-19, notably among those receiving high-flow oxygen or noninvasive ventilation. The combination was associated with fewer serious adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Biochemistry & Molecular Biology

Attributes and predictors of long COVID

Carole H. Sudre et al.

Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.

NATURE MEDICINE (2021)

Review Rheumatology

Immune cartography of macrophage activation syndrome in the COVID-19 era

Dennis McGonagle et al.

Summary: This article discusses macrophage activation syndrome (MAS) in relation to other cytokine storm scenarios, providing a framework for understanding MAS within the spectrum of innate and adaptive immunity in the context of gain or loss of immune function.

NATURE REVIEWS RHEUMATOLOGY (2021)

Article Medicine, General & Internal

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

Anthony C. Gordon et al.

Summary: Interleukin-6 receptor antagonists tocilizumab and sarilumab were found to improve outcomes, including survival, in critically ill patients with Covid-19 receiving organ support in ICUs according to an ongoing international trial. The efficacy of these treatments has been confirmed, with patients benefiting from the therapy.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Causes of death and comorbidities in hospitalized patients with COVID-19

Sefer Elezkurtaj et al.

Summary: The study conducted autopsies on 26 patients who died after SARS-CoV-2 infection and COVID-19, finding that septic shock and multi organ failure were the most common immediate causes of death, often due to suppurative pulmonary infection. Most patients had comorbidities such as hypertension, ischemic heart disease, and obesity. The majority of deaths were found to be directly related to COVID-19, with contributory implications of preexisting health conditions to the mechanism of death.

SCIENTIFIC REPORTS (2021)

Article Microbiology

Metabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab

Gaia Meoni et al.

Summary: The research analyzed the metabolites of COVID-19 patients and controls using NMR, finding common plasma metabolomic and lipidomic signatures in COVID-19 patients. Tocilizumab treatment was shown to partially reverse the metabolic alterations caused by SARS-CoV-2 infection.

PLOS PATHOGENS (2021)

Article Biology

Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

Jack Gisby et al.

Summary: Analysis of blood samples from ESKD patients with COVID-19 revealed protein markers associated with clinical severity, including epithelial damage, immune activation, and cell-cell interactions, providing potential drug targets.

ELIFE (2021)

Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

Article Nutrition & Dietetics

Carnitine and COVID-19 Susceptibility and Severity: A Mendelian Randomization Study

Chunyu Li et al.

Summary: Genetic predisposition to high carnitine levels may reduce susceptibility and severity of COVID-19, providing insights for novel therapeutic targets in future clinical trials.

FRONTIERS IN NUTRITION (2021)

Article Multidisciplinary Sciences

Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

Guillermo Leon et al.

Summary: Passive immunotherapy using equine formulations is a promising treatment for COVID-19, showing high levels of anti-viral antibodies and in vitro neutralizing capacity against SARS-CoV-2 infection. However, clinical efficacy and safety need to be tested in clinical trials to validate the preclinical quality profiles of the products. The technological strategy described in this study can be adopted by other producers, especially in low- and middle-income countries.

SCIENTIFIC REPORTS (2021)

Article Computer Science, Interdisciplinary Applications

Critical carE Database for Advanced Research (CEDAR): An automated method to support intensive care units with electronic health record data

Edward J. Schenck et al.

Summary: CEDAR is a method for automating extraction and transformation of data from EHR systems, with statistically similar performance to manually collected data in most measures, and supported pandemic response efforts during the COVID-19 surge in New York City.

JOURNAL OF BIOMEDICAL INFORMATICS (2021)

Article Multidisciplinary Sciences

The trans-omics landscape of COVID-19

Peng Wu et al.

Summary: The authors conducted blood sampling and multi-omics analysis on COVID-19 patients of various disease severities, reporting a trans-omics landscape of COVID-19. The study found differences in characteristics between patients with different disease severities, suggesting potential clues for pathophysiology and therapeutic strategies of COVID-19.

NATURE COMMUNICATIONS (2021)

Article Immunology

CAR Macrophages for SARS-CoV-2 Immunotherapy

Wenyan Fu et al.

Summary: The study found that CAR(MERTK) macrophages can mediate similar SARS-CoV-2 clearance in vitro and reduce the viral load without upregulation of proinflammatory cytokine expression. These results pave the way for further investigation of CARs for the treatment of COVID-19 patients, especially those with severe cases.

FRONTIERS IN IMMUNOLOGY (2021)

Review Cell Biology

Sphingolipids as Modulators of SARS-CoV-2 Infection

Kid Tornquist et al.

Summary: SARS-CoV-2 virus enters cells through binding with ACE2 protein and specific protease priming, while sphingolipids affect the uptake of virus particles. Inhibition of ASM function and S1P levels may be related to disease severity.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

KEGG: integrating viruses and cellular organisms

Minoru Kanehisa et al.

Summary: KEGG is a curated resource integrating eighteen databases categorized into systems, genomic, chemical and health information, providing mapping tools for understanding cellular and organism-level functions from genome sequences and other molecular datasets. The network variation maps in the KEGG database show how different pathogens and environmental factors influence cellular signaling pathways.

NUCLEIC ACIDS RESEARCH (2021)

Article Medicine, General & Internal

Clinical Characteristics of Coronavirus Disease 2019 in China

W. Guan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Biochemistry & Molecular Biology

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

Bo Shen et al.

Article Urology & Nephrology

Acute kidney injury in patients hospitalized with COVID-19

Jamie S. Hirsch et al.

KIDNEY INTERNATIONAL (2020)

Letter Medicine, General & Internal

Endothelial cell infection and endotheliitis in COVID-19

Zsuzsanna Varga et al.

LANCET (2020)

Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility

M. M. Arons et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Editorial Material Gastroenterology & Hepatology

Liver injury in COVID-19: management and challenges

Chao Zhang et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Medicine, General & Internal

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) A Review

W. Joost Wiersinga et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Letter Medicine, General & Internal

Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System

Seda Bilaloglu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Multidisciplinary Sciences

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Carolina Lucas et al.

NATURE (2020)

Article Multidisciplinary Sciences

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Prabhu S. Arunachalam et al.

SCIENCE (2020)

Review Endocrinology & Metabolism

The Impact of COVID-19 on Blood Glucose: A Systematic Review and Meta-Analysis

Juan Chen et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Biochemistry & Molecular Biology

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

Yapeng Su et al.

Article Biochemistry & Molecular Biology

Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2

Elettra Barberis et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Letter Biochemistry & Molecular Biology

Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics

Biao Di et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Multidisciplinary Sciences

Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway

Elisa Benedetti et al.

NATURE COMMUNICATIONS (2017)

Review Biochemistry & Molecular Biology

Mitochondrial dysfunction in fatty acid oxidation disorders: insights from human and animal studies

Moacir Wajner et al.

BIOSCIENCE REPORTS (2016)

Article Biochemistry & Molecular Biology

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

Walter W. Chen et al.

Article Mathematical & Computational Biology

Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data

Jan Krumsiek et al.

BMC SYSTEMS BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Presence and role of cytosine methylation in DNA viruses of animals

Karin Hoelzer et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Biochemistry & Molecular Biology

A shrinkage approach to large-scale covariance matrix estimation and implications for functional genomics

J Schafer et al.

STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY (2005)