4.7 Review

Alternative CAR Therapies: Recent Approaches in Engineering Chimeric Antigen Receptor Immune Cells to Combat Cancer

Related references

Note: Only part of the references are listed.
Review Medicine, Research & Experimental

Therapeutic potential of CAR T cell in malignancies: A scoping review

Ali Zarezadeh Mehrabadi et al.

Summary: CAR-T cell therapy shows great potential in cancer treatment, but faces challenges in treating solid tumors. Combining with other therapeutic approaches may enhance the efficacy of CAR-T cells, but further research is needed to determine their safety and effectiveness.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Article Pharmacology & Pharmacy

Comparative Efficacy of Ciltacabtagene Autoleucel in CARTITUDE-1 vs Physician's Choice of Therapy in the Long-Term Follow-Up of POLLUX, CASTOR, and EQUULEUS Clinical Trials for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma

Katja Weisel et al.

Summary: The study demonstrated that Ciltacabtagene autoleucel (cilta-cel) showed superior efficacy compared to physician's choice of treatment in patients with relapsed or refractory multiple myeloma who are triple-class exposed, including higher overall response rate, progression-free survival, and overall survival. Sensitivity analyses confirmed these findings.

CLINICAL DRUG INVESTIGATION (2022)

Article Immunology

CAR Treg: A new approach in the treatment of autoimmune diseases

Seyedeh Ameneh Beheshti et al.

Summary: Regulatory T cells (Tregs) play a crucial role in self-tolerance and immune suppression. Developing immune tolerance through Tregs cell therapy, such as CAR-T cells, shows potential for treating autoimmune diseases. CAR-T cell therapy has shown significant efficacy in leukemia treatment, and researchers are exploring its potential in auto-immune diseases.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Article Multidisciplinary Sciences

Decade-long leukaemia remissions with persistence of CD4(+) CAR T cells

J. Joseph Melenhorst et al.

Summary: CAR T cells redirected to target CD19 demonstrated long-lasting potential and clonal stability in two patients with chronic lymphocytic leukaemia. Highly activated CD4(+) cells emerged and dominated the CAR T cell population at later time points. These unexpected CAR T cell populations provide novel insights into anti-cancer response and long-term remission in leukaemia.

NATURE (2022)

Article Hematology

CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR

Haneen Shalabi et al.

Summary: This study investigated the CAR T-cell therapy for B-cell malignancies and found that CD19.22.BB zeta showed good safety and efficacy. Further optimization of combinatorial antigen targeting can overcome certain limitations.

BLOOD (2022)

Article Immunology

Novel insights in CAR-NK cells beyond CAR-T cell technology; promising advantages

Hamidreza Ebrahimiyan et al.

Summary: CAR-NK cells offer a promising alternative to CAR-T cell therapy in cancer immunotherapy. They have advantages such as lack of side effects, GvHD, and diverse cell sources, making CAR-NK therapy more feasible.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Review Oncology

CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy

Kevin Pan et al.

Summary: CAR immunotherapy has achieved significant progress in hematological malignancies, but faces challenges in solid tumors. CAR NK cells and CAR macrophages have advantages and limitations. Developing CAR macrophages could be a strategy to overcome hurdles associated with CAR therapy in solid tumors.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Article Immunology

The Interaction of HLA-C1/KIR2DL2/L3 Promoted KIR2DL2/L3 Single-Positive/NKG2C-Positive Natural Killer Cell Reconstitution, Raising the Incidence of aGVHD after Hematopoietic Stem Cell Transplantation

Wei Zuo et al.

Summary: NKG2C+ natural killer (NK) cells play a vital role in controlling CMV infection after hematopoietic stem cell transplantation (HSCT), and the reconstruction of these cells is influenced by HLA-I/KIR interactions. The study shows that specific KIR-positive NKG2C+ NK cells expand significantly after transplantation and are associated with a higher incidence of acute graft-versus-host disease.

FRONTIERS IN IMMUNOLOGY (2022)

Review Oncology

CAR-NK cells for cancer immunotherapy: from bench to bedside

Leisheng Zhang et al.

Summary: This article mainly focuses on the latest updates, opportunities, and challenges of CAR-NK cell-based tactics in cancer immunotherapy. CAR-NK cells have the potential to improve efficacy and control adverse effects, while also meeting the demand for large-scale manufacture.

BIOMARKER RESEARCH (2022)

Review Oncology

Macrophage-Based Approaches for Cancer Immunotherapy

Nicholas R. Anderson et al.

Summary: Adoptive cell therapy with genetically modified T cells has shown promising results in hematologic malignancies, but applying it to solid tumors has been challenging. This has led to the investigation of alternative immune cells as therapeutic options. Macrophages have functional plasticity that can be harnessed for both antitumor and protumor effects, leading to efforts to deplete or repolarize tumor-associated macrophages, as well as exploring the potential of adoptively transferring genetically modified macrophages.

CANCER RESEARCH (2021)

Review Biochemistry & Molecular Biology

Application of CAR-T Cell Therapy beyond Oncology: Autoimmune Diseases and Viral Infections

Ekaterina Zmievskaya et al.

Summary: Adoptive cell transfer (ACT) has been at the forefront of the battle against cancer, with the success of novel CAR-T cell technologies expanding its potential applications to other diseases. This brings new hope and possibilities to the medical field.

BIOMEDICINES (2021)

Review Biotechnology & Applied Microbiology

TCR-like CARs and TCR-CARs targeting neoepitopes: an emerging potential

Mansour Poorebrahim et al.

Summary: Neoepitopes or neoantigens are unique mutations in a patient's tumor that can be used for tumor treatment. Adoptive therapies based on T cell receptor engineering or CARs show promise in eradicating tumors while minimizing damage to normal tissues. The focus is on neoepitopes and addressing current limitations in harnessing this approach for effective and specific anti-tumor therapy.

CANCER GENE THERAPY (2021)

Article Multidisciplinary Sciences

Engineering advanced logic and distributed computing in human CAR immune cells

Jang Hwan Cho et al.

Summary: The study leverages the SUPRA CAR system to develop an inhibitory feature with three-input logic, demonstrating the effectiveness of the programmable system in various immune cells. By creating a multi-cellular NIMPLY circuit, kill switch, and synthetic intercellular communication channel, the research shows that a simple split CAR design can generate diverse and complex phenotypes.

NATURE COMMUNICATIONS (2021)

Article Cell & Tissue Engineering

HSC and iPS cell-derived CAR-NK cells as reliable cell-based therapy solutions

Jonathan Arias et al.

Summary: Research indicates that NK cell therapy is a viable option that addresses key issues in CAR cell therapy. In addition, the use of iPS cells and differentiation into HSC and NK cells offers promising solutions for industrial scalability and safety concerns.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

Review Immunology

Befriending the Hostile Tumor Microenvironment in CAR T-Cell Therapy

Lorenzo Lindo et al.

Summary: CAR T-cell therapy has shown remarkable efficacy in treating B-cell malignancies, but is hindered by local immunosuppression and toxicities such as cytokine release syndrome and neurotoxicity. Armored CAR T-cells and other combinatorial approaches are being explored to improve outcomes, although they may also increase the risk of adverse events.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors

Christopher Sloas et al.

Summary: Cellular immunotherapies, particularly using macrophages as adoptive cell therapies, show promise in treating solid tumors. Engineered CAR macrophages (CAR-M) have the potential for effective treatment against solid malignancies, highlighting the importance of manipulating immune cell function in cancer therapy.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

Implementing Logic Gates for Safer Immunotherapy of Cancer

Mohammed Azharuddin Savanur et al.

Summary: Discovering tumor-specific antigens is crucial for developing safe immunotherapy, targeting combinations of antigens co-expressed by tumor but not normal cells can reduce the risk of on-target off-tumor toxicity. Recent studies suggest that utilizing multiple antigens as targets can increase precision in cancer immunotherapy.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

Current Perspectives on Off-The-Shelf Allogeneic NK and CAR-NK Cell Therapies

Erica L. Heipertz et al.

Summary: Natural killer (NK) cells are a crucial part of the immune system, with the ability to kill virally infected and malignant cells. Current research is focused on testing the efficacy of NK cell therapy for cancer and exploring the use of CAR-NK for treatment.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany

Nawid Albinger et al.

Summary: CAR-T cell therapies and CAR-NK cell therapies are powerful immunotherapeutic tools for hematological diseases, with the latter emerging as a novel therapeutic option with advantages over the former. There are currently numerous CAR-T and CAR-NK cell trials being conducted worldwide, offering potential additional choices for clinical applications.

GENE THERAPY (2021)

Review Biochemistry & Molecular Biology

Human NK cells: From development to effector functions.

Arosh Shavinda Perera Molligoda Arachchige

Summary: NK cells, the major lymphocyte subset of the innate immune system, mediate antiviral and anti-tumor responses through natural cytotoxicity, cytokine stimulation, and Ab-dependent cellular cytotoxicity. Research on human NK cells has made significant progress in areas such as ontogeny, maturation, receptor diversity, types of responses, and effector functions.

INNATE IMMUNITY (2021)

Article Oncology

Targeting Acute Myeloid Leukemia Using the RevCAR Platform: A Programmable, Switchable and Combinatorial Strategy

Enrico Kittel-Boselli et al.

Summary: Clinical translation of novel immunotherapeutic strategies, such as CAR T-cells in AML, is still in its early stages, with challenges including immune escape and disease relapse. The development of the RevCAR platform provides a new approach to overcome these challenges and enables efficient killing of AML cells through combinatorial tumor targeting using Boolean logic gates. These achievements pave the way for improved and personalized immunotherapy for AML patients.

CANCERS (2021)

Article Cell Biology

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma

Joseph H. Choe et al.

Summary: By utilizing circuits that integrate recognition of multiple imperfect but complementary antigens, we have enhanced the specificity, completeness, and persistence of CAR T cells directed against glioblastoma, offering a general recognition strategy applicable to other solid tumors.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Review Oncology

CAR-T cell therapy: current limitations and potential strategies

Robert C. Sterner et al.

Summary: CAR-T cell therapy has shown remarkable clinical responses in certain subsets of leukemia or lymphoma, but faces challenges in solid tumors and hematological malignancies. Innovative strategies and approaches are necessary to overcome these challenges and improve the efficacy of CAR-T cells.

BLOOD CANCER JOURNAL (2021)

Article Oncology

Chimeric antigen receptor engineered NK cellular immunotherapy overcomes the selection of T-cell escape variant cancer cells

Maxwell Y. Lee et al.

Summary: The study demonstrates that resistance to T-cell killing in heterogeneous tumors can be overcome by using PD-L1 CAR-engineered NK cells, preventing clonal selection of T cell-resistant tumor cells and promoting PD-L1-dependent killing by PD-L1 t-haNKs.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Immunology

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity

Morgane Boulch et al.

Summary: Chimeric antigen receptor (CAR) T cell therapy relies on interactions with the tumor microenvironment (TME) for optimal activity, with IFN-gamma playing a crucial role in enhancing host immune response and sustaining CAR T cell cytotoxicity. CAR T cell-derived IFN-gamma facilitates host interleukin-12 production to support host immune and CAR T cell responses, highlighting the importance of cytokine-mediated cross-talk for effective CAR T cell therapy.

SCIENCE IMMUNOLOGY (2021)

Letter Oncology

IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin

Nengzhi Pang et al.

Summary: The study found that engineering human CAR-T cells to secrete human IL-7 and CCL19 (7x19) enhanced expansion and migration capabilities in vitro, and showed superior tumor suppression ability in experimental models compared to conventional CAR-T cells. In clinical trials, the incorporation of 7x19 into CAR-T cells led to significant tumor disappearance in patients with advanced HCC and PC, demonstrating the enhanced antitumor activity against human solid tumors.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Medicine, General & Internal

Ciltacabtagene autoleucel, a B-cell maturation antigendirected chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study

Jesus G. Berdeja et al.

Summary: The study aimed to evaluate the safety and clinical activity of cilta-cel in patients with relapsed or refractory multiple myeloma, and the results showed that cilta-cel treatment achieved good efficacy and safety with short treatment duration, deep response, and long duration of response.

LANCET (2021)

Article Biochemistry & Molecular Biology

CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

Jay Y. Spiegel et al.

Summary: Despite impressive progress in CAR-T cell therapy, more than 50% of patients treated with CD19-targeting CAR-T cells experience disease progression, often associated with antigen loss. To address this issue, researchers tested a bispecific CAR targeting CD19 and/or CD22, which showed high efficacy in preventing relapse in patients with B-ALL and LBCL. Antigen loss was identified as a major cause of CAR T cell resistance, emphasizing the importance of engineering multi-specific CAR T cells with equivalent potency and cytokine production as a quality indicator for potency.

NATURE MEDICINE (2021)

Article Oncology

Remote controlling of CAR-T cells and toxicity management: Molecular switches and next generation CARs

Ehsan Moghanloo et al.

Summary: Cell-based immunotherapies, particularly CAR-T cells, have shown extraordinary effects in treating hematologic malignancies such as leukemia and lymphoma. However, these therapies also come with potential immune pathologic effects that need to be carefully monitored and controlled.

TRANSLATIONAL ONCOLOGY (2021)

Article Immunology

Selective Cytotoxicity of Single and Dual Anti-CD19 and Anti-CD138 Chimeric Antigen Receptor-Natural Killer Cells against Hematologic Malignancies

Sudjit Luanpitpong et al.

Summary: CAR-NK-92 cells targeting CD19 and CD138 antigens exhibit high cytotoxicity and personalized formulation with a multitargeting approach can enhance cytotoxicity against leukemia cells.

JOURNAL OF IMMUNOLOGY RESEARCH (2021)

Review Oncology

Current Immunotherapeutic Strategies for the Treatment of Glioblastoma

Mark Dapash et al.

Summary: This review discusses various immunotherapeutic strategies currently being investigated in the treatment of glioblastoma, including checkpoint inhibitors, vaccination strategies, and CAR T-cell therapy. However, due to the low immunogenicity of the tumor, treatment outcomes remain suboptimal.

CANCERS (2021)

Review Medicine, Research & Experimental

Turning cold tumors into hot tumors by improving T-cell infiltration

Yuan-Tong Liu et al.

Summary: Immunotherapy, particularly through immune checkpoint inhibitors, has significantly improved the treatment of malignant tumors by enhancing T cell infiltration into tumors. Understanding the mechanisms underlying cold tumors, which lack T cell infiltration, is crucial to improving immunotherapy efficacy. Strategies to transform cold tumors into hot tumors and increase T cell infiltration are discussed, along with the potential of nanomedicines in enhancing tumor immunotherapy.

THERANOSTICS (2021)

Article Biochemistry & Molecular Biology

Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy

Fengzhen Mo et al.

Summary: The development of nanobody-based CAR-T cells targeting CD105 antigen has shown promising results in vitro and in vivo, exhibiting specific anti-cancer effects against solid tumors. This strategy has the potential to be an effective treatment for solid tumors by utilizing CRISPR/Cas9 technology to engineer CAR-T cells.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Hematology

Anti-CD19 CAR T-Cell Therapy for B-Cell Non-Hodgkin Lymphoma

Jeremy S. Abramson

TRANSFUSION MEDICINE REVIEWS (2020)

Article Biochemistry & Molecular Biology

Use of chimeric antigen receptor NK-92 cells to target mesothelin in ovarian cancer

Bihui Cao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

The significance of exosomes in the development and treatment of hepatocellular carcinoma

Xin Li et al.

MOLECULAR CANCER (2020)

Article Medicine, General & Internal

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

Enli Liu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Biotechnology & Applied Microbiology

Human chimeric antigen receptor macrophages for cancer immunotherapy

Michael Klichinsky et al.

NATURE BIOTECHNOLOGY (2020)

Review Oncology

Engineering CAR-T Cells for Next-Generation Cancer Therapy

Mihe Hong et al.

CANCER CELL (2020)

Article Allergy

Cytokine release syndrome and neurotoxicity following CAR T-cell therapy for hematologic malignancies

Craig W. Freyer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Review Oncology

Dual Targeting to Overcome Current Challenges in Multiple Myeloma CAR T-Cell Treatment

Jort J. van der Schans et al.

FRONTIERS IN ONCOLOGY (2020)

Article Medicine, Research & Experimental

Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris

Jinmin Lee et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Multidisciplinary Sciences

Designed protein logic to target cells with precise combinations of surface antigens

Marc J. Lajoie et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

Benjamin Salzer et al.

NATURE COMMUNICATIONS (2020)

Article Immunology

Highly Efficient Generation of Transgenically Augmented CAR NK Cells Overexpressing CXCR4

Arezoo Jamali et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Hematology

Next-generation cell therapies: the emerging role of CAR-NK cells

Rafet Basar et al.

BLOOD ADVANCES (2020)

Meeting Abstract Oncology

MOTO-CARs™: A novel macrophage-based chimeric antigen receptor technology

Michelle Hannah Townsend et al.

CANCER RESEARCH (2020)

Review Medicine, Research & Experimental

Engineering and Design of Chimeric Antigen Receptors

Sonia Guedan et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2019)

Article Biochemistry & Molecular Biology

A safe and potent anti-CD19 CAR T cell therapy

Zhitao Ying et al.

NATURE MEDICINE (2019)

Review Immunology

Targeting Tumor-Associated Macrophages in Cancer

Paulina Pathria et al.

TRENDS IN IMMUNOLOGY (2019)

Review Oncology

The Tumor Microenvironment Innately Modulates Cancer Progression

Dominique C. Hinshaw et al.

CANCER RESEARCH (2019)

Review Oncology

Multi-Specific CAR Targeting to Prevent Antigen Escape

Zachary Walsh et al.

CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2019)

Review Immunology

Tuning the Tumor Myeloid Microenvironment to Fight Cancer

Nadine S. Jahchan et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity

Shengnan Yu et al.

MOLECULAR CANCER (2019)

Article Multidisciplinary Sciences

Targeting cardiac fibrosis with engineered T cells

Haig Aghajanian et al.

NATURE (2019)

Review Oncology

Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy

Xiao Han et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Editorial Material Biotechnology & Applied Microbiology

CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart

Ronald J. Vagnozzi et al.

MOLECULAR THERAPY (2019)

Article Biotechnology & Applied Microbiology

CD 137 Co-Stimulation Improves The Antitumor Effect Of LMP1-Specific Chimeric Antigen Receptor T Cells In Vitro And In Vivo

Xiaojun Tang et al.

ONCOTARGETS AND THERAPY (2019)

Review Biochemistry & Molecular Biology

Current Progress in CAR-T Cell Therapy for Solid Tumors

Shuo Ma et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

Jang Hwan Cho et al.

Article Cell & Tissue Engineering

HBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice

Robert L. Kruse et al.

CYTOTHERAPY (2018)

Review Cell Biology

Macrophage plasticity, polarization, and function in health and disease

Abbas Shapouri-Moghaddam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Article Biotechnology & Applied Microbiology

Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

Christopher C. Kloss et al.

MOLECULAR THERAPY (2018)

Review Immunology

Regulatory T cells in autoimmune disease

Margarita Dominguez-Villar et al.

NATURE IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

Theodoros Giavridis et al.

NATURE MEDICINE (2018)

Article Medicine, General & Internal

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

S. L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Immunology

Chimeric antigen receptor T-cell approaches to HIV cure

Anne-Sophie Kuhlmann et al.

CURRENT OPINION IN HIV AND AIDS (2018)

Article Biology

Chimeric antigen receptors that trigger phagocytosis

Meghan A. Morrissey et al.

ELIFE (2018)

Review Immunology

Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies

Shangjun Sun et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

Review Immunology

Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion

Flavia Castro et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Urology & Nephrology

Peripheral Blood B Cell Depletion after Rituximab and Complete Response in Lupus Nephritis

Liliana Michelle Gomez Mendez et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Article Medicine, General & Internal

Cancer immunotherapy with CART cells - behold the future

Charlotte Graham et al.

CLINICAL MEDICINE (2018)

Article

Cytokine Release Syndrome with Chimeric Antigen Receptor T Cell Therapy

Noelle Frey et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2018)

Article Biochemistry & Molecular Biology

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages

Shicheng Su et al.

Article Multidisciplinary Sciences

Integrin CD11b activation drives anti-tumor innate immunity

Michael C. Schmid et al.

NATURE COMMUNICATIONS (2018)

Review Oncology

Tumor-associated macrophages: from basic research to clinical application

Li Yang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

Article Immunology

The Plasticity and Stability of Regulatory T Cells during Viral-Induced Inflammatory Lesions

Siddheshvar Bhela et al.

JOURNAL OF IMMUNOLOGY (2017)

Article Biotechnology & Applied Microbiology

Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes

Sigal Fishman et al.

MOLECULAR THERAPY (2017)

Article Multidisciplinary Sciences

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

Jennifer L. Guerriero et al.

NATURE (2017)

Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Medicine, Research & Experimental

Global Manufacturing of CAR T Cell Therapy

Bruce L. Levine et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2017)

Review Pathology

Mechanisms of Disease: Pemphigus and Bullous Pemphigoid

Christoph M. Hammers et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 (2016)

Article Biochemistry & Molecular Biology

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

Kole T. Roybal et al.

Article Biochemistry & Molecular Biology

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

Leonardo Morsut et al.

Review Cell Biology

Macrophages: sentinels and regulators of the immune system

Lars Franken et al.

CELLULAR MICROBIOLOGY (2016)

Article Medicine, General & Internal

Single-dose rituximab in refractory lupus nephritis

P. Kotagiri et al.

INTERNAL MEDICINE JOURNAL (2016)

Article Medicine, Research & Experimental

Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

Marco Ruella et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Multidisciplinary Sciences

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

Olivier De Henau et al.

NATURE (2016)

Article Multidisciplinary Sciences

PI3Kγ is a molecular switch that controls immune suppression

Megan M. Kaneda et al.

NATURE (2016)

Article Medicine, General & Internal

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

Christine E. Brown et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Multidisciplinary Sciences

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

Christoph T. Ellebrecht et al.

SCIENCE (2016)

Review Immunology

Harnessing NK Cell Memory for Cancer Immunotherapy

Todd A. Fehniger et al.

TRENDS IN IMMUNOLOGY (2016)

Review Oncology

Toxicity and management in CAR T-cell therapy

Challice L. Bonifant et al.

MOLECULAR THERAPY-ONCOLYTICS (2016)

Review Immunology

Tissue-resident macrophages: then and now

Luke C. Davies et al.

IMMUNOLOGY (2015)

Article Medicine, Research & Experimental

LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment

Christopher G. Pena et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Immunology

DAP12-Based Activating Chimeric Antigen Receptor for NK Cell Tumor Immunotherapy

Katrin Toepfer et al.

JOURNAL OF IMMUNOLOGY (2015)

Article Biochemistry & Molecular Biology

Contributions of B cells to lupus pathogenesis

Allison Sang et al.

MOLECULAR IMMUNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells

Dan Blat et al.

MOLECULAR THERAPY (2014)

Article Multidisciplinary Sciences

Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

Pappanaicken R. Kumaresan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes

Li Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Hematology

Progress toward inducing immunologic tolerance to factor VIII

David W. Scott et al.

BLOOD (2013)

Review Immunology

Innate and adaptive immune cells in the tumor microenvironment

Thomas F. Gajewski et al.

NATURE IMMUNOLOGY (2013)

Article Medicine, Research & Experimental

TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

Zakaria Grada et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2013)

Review Immunology

B-cell receptor: from resting state to activate

Bebhinn Treanor

IMMUNOLOGY (2012)

Article Multidisciplinary Sciences

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

Bin-Zhi Qian et al.

NATURE (2011)

Review Immunology

Natural killer cell memory

Silke Paust et al.

NATURE IMMUNOLOGY (2011)

Review Biochemistry & Molecular Biology

Pattern Recognition Receptors and Inflammation

Osamu Takeuchi et al.

Review Biochemistry & Molecular Biology

Macrophage Diversity Enhances Tumor Progression and Metastasis

Bin-Zhi Qian et al.

Review Immunology

Alternative Activation of Macrophages: Mechanism and Functions

Siamon Gordon et al.

IMMUNITY (2010)

Article Multidisciplinary Sciences

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Florent Ginhoux et al.

SCIENCE (2010)

Article Endocrinology & Metabolism

Developing a Novel Model System to Target Insulin-Reactive CD8 T Cells

Gwen S. Scott et al.

IMMUNOLOGY OF DIABETES V: FROM BENCH TO BEDSIDE (2008)

Article Gastroenterology & Hepatology

T cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytes

Felix Bohne et al.

GASTROENTEROLOGY (2008)

Review Biochemistry & Molecular Biology

The role of lymphocytes in the pathogenesis of asthma and COPD

Simonetta Baraldo et al.

CURRENT MEDICINAL CHEMISTRY (2007)

Review Immunology

Dectin-1: a signalling non-TLR pattern-recognition receptor

GD Brown

NATURE REVIEWS IMMUNOLOGY (2006)

Review Cell Biology

Mechanisms of lymphocyte migration in autoimmune disease

MU Norman et al.

TISSUE ANTIGENS (2005)

Article Biotechnology & Applied Microbiology

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCR zeta/CD28 receptor

J Maher et al.

NATURE BIOTECHNOLOGY (2002)