Related references
Note: Only part of the references are listed.P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis
Yahui Zhu et al.
HEPATOLOGY (2023)
SOAT1 enhances lung cancer invasiveness by stimulating AKT-mediated mitochondrial fragmentation
Yijun Mo et al.
BIOCHEMISTRY AND CELL BIOLOGY (2022)
Inhibition of stearoyl-CoA desaturase 1 potentiates anti-tumor activity of amodiaquine in non-small cell lung cancer
Xiaolei Hu et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2022)
Metabolic regulation of ferroptosis in the tumor microenvironment
Nneka E. Mbah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2022)
A new perspective on NAFLD: Focusing on lipid droplets
Eleonora Scorletti et al.
JOURNAL OF HEPATOLOGY (2022)
Fatty Acid Metabolism in Myeloid-Derived Suppressor Cells and Tumor-Associated Macrophages: Key Factor in Cancer Immune Evasion
Sophiya Siddiqui et al.
CANCERS (2022)
The Antianginal Drug Perhexiline Displays Cytotoxicity against Colorectal Cancer Cells In Vitro: A Potential for Drug Repurposing
Bimala Dhakal et al.
CANCERS (2022)
Ceramide-mediated gut dysbiosis enhances cholesterol esterification and promotes colorectal tumorigenesis in mice
Yahui Zhu et al.
JCI INSIGHT (2022)
SOAT1 is a new prognostic factor of colorectal cancer
Xin-Chun Wang et al.
IRISH JOURNAL OF MEDICAL SCIENCE (2022)
ATP-citrate lyase (ACLY) inhibitors as therapeutic agents: a patenting perspective
Carlotta Granchi
EXPERT OPINION ON THERAPEUTIC PATENTS (2022)
SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?
Mario Loehr et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer
Carolin Eckhardt et al.
PROSTATE CANCER AND PROSTATIC DISEASES (2022)
Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion
Nian Jiang et al.
NATURE COMMUNICATIONS (2022)
Molecular Mechanism of Lipotoxicity as an Interesting Aspect in the Development of Pathological States-Current View of Knowledge
Katarzyna Lipke et al.
CELLS (2022)
An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
Jin Zhou et al.
MOLECULAR CELL (2022)
Acetyl-CoA Synthetase 2 as a Therapeutic Target in Tumor Metabolism
Mengfang Liu et al.
CANCERS (2022)
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth
Chunming Cheng et al.
NATURE METABOLISM (2022)
Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis
Meiling Ren et al.
CELL DEATH DISCOVERY (2021)
Frontiers in the treatment of glioblastoma: Past, present and emerging
Taskeen Iqbal Janjua et al.
ADVANCED DRUG DELIVERY REVIEWS (2021)
Cancer Focus Lipid metabolism and cancer
Xueli Bian et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2021)
Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes
Montserrat A. de la Rosa Rodriguez et al.
MOLECULAR METABOLISM (2021)
Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer
Ping He et al.
BMC CANCER (2021)
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018
Quinn T. Ostrom et al.
NEURO-ONCOLOGY (2021)
Inhibition of Stearoyl-CoA Desaturase Induces the Unfolded Protein Response in Pancreatic Tumors and Suppresses Their Growth
Kaitlin Skrypek et al.
PANCREAS (2021)
Lipid Droplet Contact Sites in Health and Disease
Eva Herker et al.
TRENDS IN CELL BIOLOGY (2021)
Amide-Substituted Condensed Pyridine Derivatives as ACSS2 Inhibitors for Treating Cancer
Ram W. Sabnis
ACS Medicinal Chemistry Letters (2021)
Novel Substituted Tetrazoles as ACSS2 Inhibitors for Treating Cancer
Ram W. Sabnis
ACS Medicinal Chemistry Letters (2021)
Lipid Metabolism Influence on Neurodegenerative Disease Progression: Is the Vehicle as Important as the Cargo?
Raja Elizabeth Estes et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)
SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis
Tingting Zhu et al.
FRONTIERS IN PHARMACOLOGY (2021)
Lipid Droplets, the Central Hub Integrating Cell Metabolism and the Immune System
Wei Zhang et al.
FRONTIERS IN PHYSIOLOGY (2021)
Lipid metabolism in cancer: New perspectives and emerging mechanisms
Lindsay A. Broadfield et al.
DEVELOPMENTAL CELL (2021)
Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells
Alejandro Morales et al.
LABORATORY INVESTIGATION (2021)
Lipid Droplets, Phospholipase A2, Arachidonic Acid, and Atherosclerosis
Miguel A. Bermudez et al.
BIOMEDICINES (2021)
Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer
Yuan Liu et al.
PROSTAGLANDINS & OTHER LIPID MEDIATORS (2021)
DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis
Leilei Xia et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2021)
A Systematic Review of Glioblastoma-Targeted Therapies in Phases II, III, IV Clinical Trials
Elisabete Cruz Da Silva et al.
CANCERS (2021)
Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma
Yulong Chen et al.
BMC CANCER (2021)
LPCAT1 overexpression promotes the progression of hepatocellular carcinoma
Rong-Quan He et al.
CANCER CELL INTERNATIONAL (2021)
Mammalian lipids: structure, synthesis and function
Shamshad Cockcroft
UNDERSTANDING BIOCHEMISTRY 7 (2021)
Lipid Droplet Biosynthesis Impairment through DGAT2 Inhibition Sensitizes MCF7 Breast Cancer Cells to Radiation
Clelia Nistico et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity
Haejin Yoon et al.
MOLECULAR CELL (2021)
Simultaneous silencing of lysophosphatidylcholine acyltransferases 1-4 by nucleic acid nanoparticles (NANPs) improves radiation response of melanoma cells
Renata F. Saito et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)
Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance
Wei Wu et al.
PHARMACOLOGICAL RESEARCH (2021)
SREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth
Tong-bing Wang et al.
CELL DEATH & DISEASE (2021)
LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma
Mingyue Tao et al.
CELL DEATH & DISEASE (2021)
Lipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance
Luca Tirinato et al.
ELIFE (2021)
Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics Era
Qimin Hai et al.
METABOLITES (2021)
Clinicalpathologic and Prognostic Significance of CGI-58 in Endometrial Cancer
Zhengzheng Shi et al.
JOURNAL OF CANCER (2021)
ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway
Guohua Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
Tumour fatty acid metabolism in the context of therapy resistance and obesity
Andrew J. Hoy et al.
NATURE REVIEWS CANCER (2021)
Cancer metabolism: looking forward
Inmaculada Martinez-Reyes et al.
NATURE REVIEWS CANCER (2021)
First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors
Gerald Falchook et al.
ECLINICALMEDICINE (2021)
Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
Ryan M. Esquejo et al.
CELL CHEMICAL BIOLOGY (2021)
LXR alpha activation and Raf inhibition trigger lethal lipotoxicity in liver cancer
Ramona Rudalska et al.
NATURE CANCER (2021)
The functional universe of membrane contact sites
William A. Prinz et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Fatostatin inhibits the development of endometrial carcinoma in endometrial carcinoma cells and a xenograft model by targeting lipid metabolism
Lan Yao et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)
Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer
Marteinn Thor Snaebjornsson et al.
CELL METABOLISM (2020)
CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential
Isabel R. Schlaepfer et al.
ENDOCRINOLOGY (2020)
A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma
David C. Smith et al.
INVESTIGATIONAL NEW DRUGS (2020)
Mechanisms and regulation of cholesterol homeostasis
Jie Luo et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Lipid droplets: platforms with multiple functions in cancer hallmarks
Andre L. S. Cruz et al.
CELL DEATH & DISEASE (2020)
TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
Cyril Corbet et al.
NATURE COMMUNICATIONS (2020)
Lipid Droplets Define a Sub-Population of Breast Cancer Stem Cells
Benjamin J. Hershey et al.
JOURNAL OF CLINICAL MEDICINE (2020)
Glioblastoma multiforme: novel therapeutic targets
Matthew Muir et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2020)
New kid on the block: lipid droplets in the nucleus
Antonio D. Barbosa et al.
FEBS JOURNAL (2020)
Lipid droplets throughout the evolutionary tree
Peter K. Lundquist et al.
PROGRESS IN LIPID RESEARCH (2020)
Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor
Chengcheng Guan et al.
NATURE COMMUNICATIONS (2020)
Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma
Shiva Kant et al.
MOLECULAR CANCER THERAPEUTICS (2020)
Structure and mechanism of human diacylglycerol O-acyltransferase 1
Wang Lie et al.
NATURE (2020)
Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme
Sui Xuewu et al.
NATURE (2020)
Structural basis for catalysis and substrate specificity of human ACAT1
Qian Hongwu et al.
NATURE (2020)
Structure of nevanimibe-bound tetrameric human ACAT1
Long Tao et al.
NATURE (2020)
CHOLESTEROL REVIEW: A METABOLICALLY IMPORTANT MOLECULE
David S. Schade et al.
ENDOCRINE PRACTICE (2020)
Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress
Xiang Cheng et al.
CELL METABOLISM (2020)
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer
Tobiloba E. Oni et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2020)
Protein Quality Control and Lipid Droplet Metabolism
Melissa A. Roberts et al.
Annual Review of Cell and Developmental Biology (2020)
The discovery of lipid droplets: A brief history of organelles hidden in plain sight
Rosalind A. Coleman
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2020)
Regulation of lipid droplet homeostasis by hypoxia inducible lipid droplet associated HILPDA
Montserrat A. de la Rosa Rodriguez et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2020)
Lipid Droplets Maintain Energy Homeostasis and Glioblastoma Growth via Autophagic Release of Stored Fatty Acids
Xiaoning Wu et al.
ISCIENCE (2020)
A metastasis map of human cancer cell lines
Xin Jin et al.
NATURE (2020)
Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases
Sabina Cisa-Wieczorek et al.
CELLS (2020)
The dynamic behavior of lipid droplets in the pre-metastatic niche
Chunliang Shang et al.
CELL DEATH & DISEASE (2020)
Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells
Colin Rae et al.
ADVANCES IN RADIATION ONCOLOGY (2020)
Hypoxia, hypoxia-inducible gene 2 (HIG2)/HILPDA, and intracellular lipolysis in cancer
Davide Povero et al.
CANCER LETTERS (2020)
The interaction between ferroptosis and lipid metabolism in cancer
Dingshan Li et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma
James S. Lally et al.
CELL METABOLISM (2019)
A specific lipid metabolic profile is associated with the epithelial mesenchymal transition program
Anna Maria Giudetti et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2019)
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma
Ying Jiang et al.
NATURE (2019)
What is 'LDL cholesterol'?
Michael V. Holmes et al.
NATURE REVIEWS CARDIOLOGY (2019)
Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
Kamil Soltysik et al.
NATURE COMMUNICATIONS (2019)
DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130
Francesca Nardi et al.
SCIENTIFIC REPORTS (2019)
Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review
Pengxu Lei et al.
FRONTIERS IN PHYSIOLOGY (2019)
SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals
Kelin She et al.
CANCER CELL INTERNATIONAL (2019)
Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells
Larissa Menezes dos Reis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Metabolic regulation of TH17 cells
Hongxing Shen et al.
MOLECULAR IMMUNOLOGY (2019)
Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
Junfeng Bi et al.
CELL METABOLISM (2019)
Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer
Patrick Lebok et al.
AGING-US (2019)
SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity
Fan Yin et al.
CELL DEATH & DISEASE (2019)
Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
Weihua Zhou et al.
CANCERS (2019)
Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages
Hao Wu et al.
EMBO MOLECULAR MEDICINE (2019)
Phospholipid Remodeling in Physiology and Disease
Bo Wang et al.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 81 (2019)
SREBP-2 aggravates breast cancer associated osteolysis by promoting osteoclastogenesis and breast cancer metastasis
Zhiwei Jie et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)
Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer
Seher Balaban et al.
MOLECULAR CANCER RESEARCH (2019)
Dynamics and functions of lipid droplets
James A. Olzmann et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
Astrocytoma progression scoring system based on the WHO 2016 criteria
Zhen-Hang Li et al.
SCIENTIFIC REPORTS (2019)
An Asymmetry in Monolayer Tension Regulates Lipid Droplet Budding Direction
Aymeric Chorlay et al.
BIOPHYSICAL JOURNAL (2018)
The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets
Anete Romanauska et al.
CELL (2018)
SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Meta-bolic Targets in Cancer Therapy
Xiang Cheng et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2018)
A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes
Kirill Bersuker et al.
DEVELOPMENTAL CELL (2018)
Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency
Jorik M. van Rijn et al.
GASTROENTEROLOGY (2018)
Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions
Dijin Xu et al.
JOURNAL OF CELL BIOLOGY (2018)
Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer
Yang-An Wen et al.
CELL DEATH & DISEASE (2018)
The carnitine system and cancer metabolic plasticity
Mariarosa Anna Beatrice Melone et al.
CELL DEATH & DISEASE (2018)
Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact
Nadav Shai et al.
NATURE COMMUNICATIONS (2018)
Insensitivity to atorvastatin is associated with increased accumulation of intracellular lipid droplets and fatty acid metabolism in breast cancer cells
Barbara Lettiero et al.
SCIENTIFIC REPORTS (2018)
The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia
Julian Hlouschek et al.
FRONTIERS IN ONCOLOGY (2018)
Retrospective on Cholesterol Homeostasis: The Central Role of Scap
Michael S. Brown et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)
Role of DGAT enzymes in triacylglycerol metabolism
Bhumika Bhatt-Wessel et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2018)
Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer
Viktor Brovkovych et al.
ONCOGENESIS (2018)
Ibrutinib Resistance Is Reduced by an Inhibitor of Fatty Acid Oxidation in Primary CLL Lymphocytes
Gabriela Galicia-Vazquez et al.
FRONTIERS IN ONCOLOGY (2018)
Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma
Maria Elena Pisanu et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)
Lipid metabolism reprogramming and its potential targets in cancer
Chunming Cheng et al.
CANCER COMMUNICATIONS (2018)
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Valerian E. Kagan et al.
NATURE CHEMICAL BIOLOGY (2017)
Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma
Yiqing Du et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)
European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas
Michael Weller et al.
LANCET ONCOLOGY (2017)
Lipid Droplets in Health and Disease
Gizem Onal et al.
LIPIDS IN HEALTH AND DISEASE (2017)
Applying systems-level spectral imaging and analysis to reveal the organelle interactome
Alex M. Valm et al.
NATURE (2017)
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
Filippo Veglia et al.
NATURE COMMUNICATIONS (2017)
Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade
Thomas W. Flaig et al.
ONCOTARGET (2017)
Blockade of Stearoyl-CoA-desaturase 1 activity reverts resistance to cisplatin in lung cancer stem cells
Maria Elena Pisanu et al.
CANCER LETTERS (2017)
Positive regulation of prostate cancer cell growth by lipid droplet forming and processing enzymes DGAT1 and ABHD5
Ranjana Mitra et al.
BMC CANCER (2017)
Site-1 protease, a novel metabolic target for glioblastoma
Beth T. Caruana et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
ER Membrane Phospholipids and Surface Tension Control Cellular Lipid Droplet Formation
Kalthoum Ben M'barek et al.
DEVELOPMENTAL CELL (2017)
Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation
Siqingaowa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets
Can E. Senkal et al.
CELL METABOLISM (2017)
Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells
Junjie Li et al.
CELL STEM CELL (2017)
Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer
Takashi Uehara et al.
ANNALS OF SURGICAL ONCOLOGY (2016)
Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection
Florian Ringel et al.
NEURO-ONCOLOGY (2016)
PD-L1 expression and prognostic impact in glioblastoma
Edjah K. Nduom et al.
NEURO-ONCOLOGY (2016)
Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR
Sue Ellen Verbrugge et al.
ONCOTARGET (2016)
Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6
Harrison Penrose et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
The physics of lipid droplet nucleation, growth and budding
Abdou Rachid Thiam et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2016)
Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis
Feng Geng et al.
CLINICAL CANCER RESEARCH (2016)
Congenital protein losing enteropathy: an inborn error of lipid metabolism due to DGAT1 mutations
Joshi Stephen et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2016)
PML isoform II plays a critical role in nuclear lipid droplet formation
Yuki Ohsaki et al.
JOURNAL OF CELL BIOLOGY (2016)
Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment
Meric Erikci Ertunc et al.
JOURNAL OF LIPID RESEARCH (2016)
Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes
Jean-Pierre Etchegaray et al.
MOLECULAR CELL (2016)
The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila
Shree Ram Singh et al.
NATURE (2016)
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models
Robert U. Svensson et al.
NATURE MEDICINE (2016)
Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma
Dong-ye Mao et al.
ONCOTARGET (2016)
Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells
Jiajin Li et al.
ONCOTARGET (2016)
SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase
Martin Pagac et al.
CELL REPORTS (2016)
Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth
Peng Ru et al.
CELL REPORTS (2016)
Seipin is required for converting nascent to mature lipid droplets
Huajin Wang et al.
ELIFE (2016)
Analysis of SCAP N-glycosylation and Trafficking in Human Cells
Chunming Cheng et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2016)
Morphologically and Functionally Distinct Lipid Droplet Subpopulations
Shuyan Zhang et al.
SCIENTIFIC REPORTS (2016)
The multifaceted roles of fatty acid synthesis in cancer
Florian Roehrig et al.
NATURE REVIEWS CANCER (2016)
SCAP links glucose to lipid metabolism in cancer cells
Deliang Guo
MOLECULAR & CELLULAR ONCOLOGY (2016)
Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias
Maria Rosaria Ricciardi et al.
BLOOD (2015)
Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth
Chunming Cheng et al.
CANCER CELL (2015)
A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
Joseph L. Goldstein et al.
CELL (2015)
Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation
Narayana P. B. Fazolini et al.
CELL CYCLE (2015)
Cholesterol trafficking and distribution
David B. Iaea et al.
MEMBRANE NANODOMAINS (2015)
ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease
Yohei Shibuya et al.
FUTURE MEDICINAL CHEMISTRY (2015)
A conserved family of proteins facilitates nascent lipid droplet budding from the ER
Vineet Choudhary et al.
JOURNAL OF CELL BIOLOGY (2015)
K604, a specific acyl-CoA:cholesterol acyltransferase 1 inhibitor, suppresses proliferation of U251-MG glioblastoma Cells
Takuji Ohmoto et al.
MOLECULAR MEDICINE REPORTS (2015)
Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
Sriram Venneti et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma
Anna Sophie Berghoff et al.
NEURO-ONCOLOGY (2015)
FTIR spectroscopy reveals lipid droplets in drug resistant laryngeal carcinoma cells through detection of increased ester vibrational bands intensity
Sanjica Rak et al.
ANALYST (2014)
Glioblastoma: From Molecular Pathology to Targeted Treatment
Timothy F. Cloughesy et al.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9 (2014)
Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
Tomoyuki Mashimo et al.
CELL (2014)
Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness
Shuhua Yue et al.
CELL METABOLISM (2014)
Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer
Deliang Guo et al.
CURRENT PHARMACEUTICAL DESIGN (2014)
Rab8a-AS160-MSS4 Regulatory Circuit Controls Lipid Droplet Fusion and Growth
Lizhen Wu et al.
DEVELOPMENTAL CELL (2014)
Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics
William A. Prinz
JOURNAL OF CELL BIOLOGY (2014)
Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis
Susanne Grube et al.
JOURNAL OF NEURO-ONCOLOGY (2014)
Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer
Isabel R. Schlaepfer et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling
Xiangyan Li et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Lipid landscapes and pipelines in membrane homeostasis
Joost C. M. Holthuis et al.
NATURE (2014)
A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
Mark R. Gilbert et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Nuclear lipid droplets: A novel nuclear domain
J. P. Layerenza et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)
An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Kevin J. Williams et al.
CANCER RESEARCH (2013)
The Somatic Genomic Landscape of Glioblastoma
Cameron W. Brennan et al.
CELL (2013)
Cellular Fatty Acid Metabolism and Cancer
Erin Currie et al.
CELL METABOLISM (2013)
The Definition of Primary and Secondary Glioblastoma
Hiroko Ohgaki et al.
CLINICAL CANCER RESEARCH (2013)
Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma
Christina A. von Roemeling et al.
CLINICAL CANCER RESEARCH (2013)
Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets
Florian Wilfling et al.
DEVELOPMENTAL CELL (2013)
FOXO3 Growth Inhibition of Colonic Cells Is Dependent on Intraepithelial Lipid Droplet Density
Wentao Qi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Specific Accumulation of Lipid Droplets in Hepatocyte Nuclei of PFOA-exposed BALB/c Mice
Ling Wang et al.
SCIENTIFIC REPORTS (2013)
A clinical review of treatment outcomes in glioblastoma multiforme-the validation in a non-trial population of the results of a randomised Phase III clinical trial: has a more radical approach improved survival?
K. Rock et al.
BRITISH JOURNAL OF RADIOLOGY (2012)
Controlling the size of lipid droplets: lipid and protein factors
Hongyuan Yang et al.
CURRENT OPINION IN CELL BIOLOGY (2012)
Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets
Kai Hsieh et al.
JOURNAL OF CELL SCIENCE (2012)
The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and-2
Jenson Qi et al.
JOURNAL OF LIPID RESEARCH (2012)
Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxel
Isabel R. Schlaepfer et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)
Translation Inhibitors Induce Formation of Cholesterol Ester-Rich Lipid Droplets
Michitaka Suzuki et al.
PLOS ONE (2012)
SREBPs: metabolic integrators in physiology and metabolism
Tae-Il Jeon et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites
Jingyi Gong et al.
JOURNAL OF CELL BIOLOGY (2011)
Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia
Renata M. Oballa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation
David A. Gross et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1
Robert L. Dow et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway
Deliang Guo et al.
CANCER DISCOVERY (2011)
Lipid droplets: size matters
Michitaka Suzuki et al.
JOURNAL OF ELECTRON MICROSCOPY (2011)
AMPK A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas
Deliang Guo et al.
CELL CYCLE (2010)
Cholesterol, the central lipid of mammalian cells
Frederick R. Maxfield et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Acyl-coenzyme A: cholesterol acyltransferases
Ta-Yuan Chang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
The LDL Receptor
Joseph L. Goldstein et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)
Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases
Gema Perez-Chacon et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2009)
Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma
Henry S. Friedman et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
Deliang Guo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy
Deliang Guo et al.
SCIENCE SIGNALING (2009)
Quantitative Label-Free Imaging of Lipid Composition and Packing of Individual Cellular Lipid Droplets Using Multiplex CARS Microscopy
Hilde A. Rinia et al.
BIOPHYSICAL JOURNAL (2008)
Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance
Arun Radhakrishnan et al.
CELL METABOLISM (2008)
Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast
Weihua Fei et al.
JOURNAL OF CELL BIOLOGY (2008)
Cellular cholesterol trafficking and compartmentalization
Elina Ikonen
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Membrane lipids: where they are and how they behave
Gerrit van Meer et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology
Kimberly M. Szymanski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins
Li-Ping Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Liver X receptors as integrators of metabolic and inflammatory signaling
N Zelcer et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Protein sensors for membrane sterols
JL Goldstein et al.
CELL (2006)
ATP citrate lyase inhibition can suppress tumor cell growth
G Hatzivassiliou et al.
CANCER CELL (2005)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
R Stupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Lipopenia and skin barrier abnormalities in DGAT2-deficient mice
SJ Stone et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cholesterol-induced conformational change in SCAP enhanced by insig proteins and mimicked by cationic amphiphiles
CM Adams et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells - A role for cardiolipin
S Hardy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
LL Listenberger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis
JD Horton
BIOCHEMICAL SOCIETY TRANSACTIONS (2002)
Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER
PJ Espenshade et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
T Yang et al.
CELL (2002)
Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members
S Cases et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
SJ Smith et al.
NATURE GENETICS (2000)