Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage

Article Gastroenterology & Hepatology

P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis

Yahui Zhu et al.

Summary: This study reveals the important role of tumor suppressor P53 in maintaining cholesterol ester homeostasis and demonstrates the dysregulation of the P53-USP19-SOAT1 signaling axis in human HCC.

HEPATOLOGY (2023)

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Article Biochemistry & Molecular Biology

SOAT1 enhances lung cancer invasiveness by stimulating AKT-mediated mitochondrial fragmentation

Yijun Mo et al.

Summary: SOAT1 plays a vital role in lung cancer invasion by regulating intracellular free cholesterol levels and activating the PI3K/AKT signaling pathway, which promotes cancer cell invasion and mitochondrial fragmentation.

BIOCHEMISTRY AND CELL BIOLOGY (2022)

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Article Pharmacology & Pharmacy

Inhibition of stearoyl-CoA desaturase 1 potentiates anti-tumor activity of amodiaquine in non-small cell lung cancer

Xiaolei Hu et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2022)

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Review Biochemistry & Molecular Biology

Metabolic regulation of ferroptosis in the tumor microenvironment

Nneka E. Mbah et al.

Summary: In this article, the intrinsic and extrinsic factors that promote the sensitivity of cancer cells to ferroptosis were reviewed, including the components of the tumor microenvironment. Also, the potential therapeutic options for cancer therapy utilizing ferroptotic agents were described.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

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Review Gastroenterology & Hepatology

A new perspective on NAFLD: Focusing on lipid droplets

Eleonora Scorletti et al.

Summary: This review discusses the mechanisms by which lipid droplet (LD) accumulation in hepatocytes contributes to the progression of non-alcoholic fatty liver disease (NAFLD). It highlights the importance of LD architecture and the dysregulation of LD biogenesis, leading to endoplasmic reticulum stress and inflammation. The causal nexus between LD proteome composition and LD degradation is also analyzed. Additionally, the review describes how the increase in size of LDs activates hepatic stellate cells, leading to liver fibrosis and hepatocellular carcinoma.

JOURNAL OF HEPATOLOGY (2022)

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Review Oncology

Fatty Acid Metabolism in Myeloid-Derived Suppressor Cells and Tumor-Associated Macrophages: Key Factor in Cancer Immune Evasion

Sophiya Siddiqui et al.

Summary: This review article discusses the influence of metabolic changes in the tumor microenvironment on immune cells, with a focus on the role of fatty acids stored in lipid droplets. Understanding the importance of lipid droplets in modulating immune cell function and phenotype is crucial for identifying new therapeutic targets and addressing immunosuppression in cancer.

CANCERS (2022)

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Article Oncology

The Antianginal Drug Perhexiline Displays Cytotoxicity against Colorectal Cancer Cells In Vitro: A Potential for Drug Repurposing

Bimala Dhakal et al.

Summary: Cancer cells have altered metabolism to support their activities, and Perhexiline, a cardiovascular drug, can inhibit these changes and kill colorectal cancer cells. This drug has been used clinically and has the potential for repurposing in colorectal cancer management.

CANCERS (2022)

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Article Medicine, Research & Experimental

Ceramide-mediated gut dysbiosis enhances cholesterol esterification and promotes colorectal tumorigenesis in mice

Yahui Zhu et al.

Summary: This study reveals the important role of ceramide and sterol O-acyltransferase 1 (SOAT1) in the development of colorectal cancer. By promoting gut dysbiosis and cholesterol esterification, ceramide contributes to tumorigenesis. The SOAT1 inhibitor avasimibe shows significant therapeutic effects on colorectal cancer.

JCI INSIGHT (2022)

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Article Medicine, General & Internal

SOAT1 is a new prognostic factor of colorectal cancer

Xin-Chun Wang et al.

Summary: SOAT1 plays a critical role in colorectal cancer metastasis, with high expression correlating with lymph node metastasis and poor patient survival rates. Targeting the activity of SOAT1 may be a promising therapeutic strategy for preventing the metastasis of colorectal cancer.

IRISH JOURNAL OF MEDICAL SCIENCE (2022)

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Article Chemistry, Medicinal

ATP-citrate lyase (ACLY) inhibitors as therapeutic agents: a patenting perspective

Carlotta Granchi

Summary: ATP citrate lyase (ACLY) is a key enzyme in cellular metabolism, involved in fatty acid synthesis and cancer occurrence. This review focuses on ACLY inhibitors and alternative strategies to modulate ACLY activity for potential therapeutic applications. Currently, effective ACLY inhibitors are limited due to low cell penetration and affinity. Further research on new ACLY inhibitors is of great significance for lipid-related pathologies and cancer treatment.

EXPERT OPINION ON THERAPEUTIC PATENTS (2022)

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Article Biochemistry & Molecular Biology

SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?

Mario Loehr et al.

Summary: Inhibition of SOAT1 may serve as a therapeutic option to target the growth and invasiveness of glioblastoma (GBM) and astrocytoma (HGA). Additionally, it could also suppress protumoral microglia/macrophages associated with neuroinflammation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer

Carolin Eckhardt et al.

Summary: In high-risk prostate cancer patients, high SOAT1 expression is strongly associated with shorter BCR-free survival, while SOAT2 expression is not significant. High SOAT1 expression remains significantly associated with shorter BCR-free survival after multivariable adjustment, suggesting SOAT1 may serve as a histologic marker of prognosis and a potential treatment target in the future.

PROSTATE CANCER AND PROSTATIC DISEASES (2022)

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Article Multidisciplinary Sciences

Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion

Nian Jiang et al.

Summary: This study reveals that the co-enhancement of mitochondrial fatty acid oxidation (FAO) enzymes and immune checkpoint CD47 is dominant in recurrent GBM patients with poor prognosis. Inhibition of FAO can impair tumor growth and reduce CD47 anti-phagocytosis, and combining FAO inhibition and anti-CD47 antibody can enhance radiation control of regrown tumors and boost macrophage phagocytosis.

NATURE COMMUNICATIONS (2022)

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Review Cell Biology

Molecular Mechanism of Lipotoxicity as an Interesting Aspect in the Development of Pathological States-Current View of Knowledge

Katarzyna Lipke et al.

Summary: Free fatty acids (FFAs) play vital roles in the organism but disturbances in fatty acid homeostasis can lead to lipotoxicity, contributing to the development of diseases such as insulin resistance and diabetes. Lipotoxic effects primarily affect organs such as the pancreas, liver, skeletal muscles, cardiac muscle, and kidneys.

CELLS (2022)

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Article Biochemistry & Molecular Biology

An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma

Jin Zhou et al.

Summary: The JMJD6-DGAT1 axis plays a critical role in ccRCC tumor development. JMJD6 interacts with RBM39 and co-occupies the DGAT1 gene promoter to induce DGAT1 expression. Silencing JMJD6 reduces DGAT1 expression, leading to inhibition of lipid droplet formation and tumorigenesis. Pharmacological inhibition of DGAT1 suppresses lipid droplet formation and ccRCC tumorigenesis.

MOLECULAR CELL (2022)

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Review Oncology

Acetyl-CoA Synthetase 2 as a Therapeutic Target in Tumor Metabolism

Mengfang Liu et al.

Summary: Acetyl-CoA Synthetase 2 (ACSS2) is highly expressed in various tumors and plays an important role in tumor growth, proliferation, invasion, and metastasis under nutritional stress. ACSS2 inhibitors have shown effectiveness in halting cancer growth and can be used in combination with other antineoplastic drugs to reduce drug resistance. This article reviews the mechanisms of ACSS2-promoting tumor growth and the potential clinical application of targeted inhibitors.

CANCERS (2022)

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Article Endocrinology & Metabolism

Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth

Chunming Cheng et al.

Summary: In this study, researchers found that ammonia released from glutaminolysis activates SREBP-1 and promotes lipogenesis, thus supporting tumor growth. The study reveals the role of ammonia as a key activator in promoting lipid synthesis through dissociation of SCAP-Insig and activation of SREBP-1. It also demonstrates the critical role of SCAP as a sensor for glutamine, glucose, and sterol levels in precise control of lipid synthesis.

NATURE METABOLISM (2022)

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Article Cell Biology

Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis

Meiling Ren et al.

Summary: Lipid homeostasis is crucial in the development of hepatocellular carcinoma (HCC), and a study found that a high-fat diet can improve lipid homeostasis in HCC. The study identified a double-negative feedback loop between SOAT1 and CPT1A in HCC, where SOAT1 inhibition enhanced CPT1A protein expression to shuttle fatty acids for oxidation. Targeting both SOAT1 and CPT1A with small-molecule inhibitors avasimibe and etomoxir showed synergistic anticancer efficacy in vitro and in vivo, suggesting a novel strategy for HCC treatment.

CELL DEATH DISCOVERY (2021)

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Review Pharmacology & Pharmacy

Frontiers in the treatment of glioblastoma: Past, present and emerging

Taskeen Iqbal Janjua et al.

Summary: Glioblastoma is a highly aggressive brain cancer with low survival rates and strong resistance to existing treatments. Current therapies have not been effective in prolonging patient survival, highlighting the need for new treatment approaches such as novel delivery technologies and materials.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Immunology

Cancer Focus Lipid metabolism and cancer

Xueli Bian et al.

Summary: Dysregulation of lipid metabolism plays a significant role in cancer progression, and understanding the regulation and disruption of lipid metabolism in cancer cells have led to promising clinical approaches in cancer therapy.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Endocrinology & Metabolism

Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes

Montserrat A. de la Rosa Rodriguez et al.

Summary: HILPDA interacts physically with DGAT1 in liver cells, increasing DGAT activity and promoting lipid storage, suggesting a novel regulatory mechanism by which fatty acids enhance triglyceride synthesis and storage.

MOLECULAR METABOLISM (2021)

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Article Oncology

Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer

Ping He et al.

Summary: The research revealed that high expression of DGAT1 in gastric cancer tissues and tumor infiltrating macrophages is associated with poor prognosis in gastric cancer patients, indicating that inhibiting DGAT1 could be a promising strategy for gastric cancer treatment.

BMC CANCER (2021)

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Article Oncology

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018

Quinn T. Ostrom et al.

Summary: The report from CBTRUS provides the most up-to-date population-based data on primary brain tumors in the United States, including incidence rates, mortality rates, and survival rates for both malignant and non-malignant tumors.

NEURO-ONCOLOGY (2021)

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Article Gastroenterology & Hepatology

Inhibition of Stearoyl-CoA Desaturase Induces the Unfolded Protein Response in Pancreatic Tumors and Suppresses Their Growth

Kaitlin Skrypek et al.

Summary: In this study, it was found that inhibition of the SCD enzyme can induce cell death in early pancreatic tumors and activate the unfolded protein response. Oleic acid can alleviate the inhibitory effects on growth in organoids, whereas stearic acid cannot, and the SCD inhibitor suppresses growth in pancreatic cancer cell lines without inducing cell death.

PANCREAS (2021)

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Article Cell Biology

Lipid Droplet Contact Sites in Health and Disease

Eva Herker et al.

Summary: Lipid droplets, once seen as inert fat drops, are now recognized as vital organelles with key functions in lipid biology and cellular communication. Diseases factors mutated in hereditary disorders have been linked to LD contact site proteins, indicating the importance of LD-organelle contacts in disease development and progression. Additionally, LD contact sites are dynamically rearranged in response to infections and pathological metabolic conditions, suggesting their crucial role in disease pathways.

TRENDS IN CELL BIOLOGY (2021)

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Article Chemistry, Medicinal

Amide-Substituted Condensed Pyridine Derivatives as ACSS2 Inhibitors for Treating Cancer

Ram W. Sabnis

ACS Medicinal Chemistry Letters (2021)

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Article Chemistry, Medicinal

Novel Substituted Tetrazoles as ACSS2 Inhibitors for Treating Cancer

Ram W. Sabnis

ACS Medicinal Chemistry Letters (2021)

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Review Neurosciences

Lipid Metabolism Influence on Neurodegenerative Disease Progression: Is the Vehicle as Important as the Cargo?

Raja Elizabeth Estes et al.

Summary: The pathogenesis of neurodegenerative diseases involves both the formation of pathogenic protein aggregates and their spread throughout the nervous system. Alterations in lipid metabolism and dysregulation of extracellular vesicles are considered key factors accelerating the spread of protein aggregation and disease progression.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

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Article Pharmacology & Pharmacy

SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis

Tingting Zhu et al.

Summary: Metabolic reprogramming is a hallmark of malignancies such as gastric cancer, with the rate-limiting enzyme SOAT1 identified as highly expressed in cancerous tissues and associated with advanced tumor stage and lymph node metastasis. Inhibition of SOAT1 suppresses GC cell proliferation, cholesterol ester synthesis, and lymphangiogenesis, while overexpression promotes these processes by regulating cholesterol metabolism genes. Therefore, SOAT1 may serve as a promising prognostic biomarker for guiding clinical management and treatment decisions in gastric cancer.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Physiology

Lipid Droplets, the Central Hub Integrating Cell Metabolism and the Immune System

Wei Zhang et al.

Summary: Lipid droplets (LDs) are organelles related to cell metabolism, composed of polar lipids and proteins on the surface with neutral lipids in the core. LDs play a pivotal role in various physiological and pathological processes, including antitumor immunity, anti-infective immunity, and metabolic immune diseases. Additionally, the interaction between LDs and immune cells is analyzed in atherosclerosis and Mycobacterium tuberculosis infection.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Cell Biology

Lipid metabolism in cancer: New perspectives and emerging mechanisms

Lindsay A. Broadfield et al.

Summary: Tumors undergo metabolic changes to support growth, and increasing focus on cancer lipid metabolism has revealed mechanisms promoting tumor growth and survival that are distinct from traditional cellular bioenergetics. Targeting lipid metabolism for anticancer therapy shows promise, but there are still unanswered questions in this field.

DEVELOPMENTAL CELL (2021)

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Article Medicine, Research & Experimental

Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells

Alejandro Morales et al.

Summary: The study reveals that EPHB2 deficiency in prostate cancer cells results in abnormal accumulation of lipid droplets and increased cell proliferation, mainly by regulating the key proteins DGAT1 and ATGL involved in lipid metabolism.

LABORATORY INVESTIGATION (2021)

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Article Biochemistry & Molecular Biology

Lipid Droplets, Phospholipase A2, Arachidonic Acid, and Atherosclerosis

Miguel A. Bermudez et al.

Summary: Lipid droplets, previously seen as static storage organelles, are now recognized as dynamic structures involved in key processes like lipid metabolism, cellular homeostasis, and signaling. Circulating monocytes may interact with products released by endothelial cells in atherosclerotic plaques, potentially acquiring a foamy phenotype before differentiating into macrophages. Arachidonic acid, released in significant amounts into the bloodstream, acts as a potent inducer of neutral lipid synthesis and lipid droplet formation in circulating monocytes.

BIOMEDICINES (2021)

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Article Biochemistry & Molecular Biology

Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer

Yuan Liu et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2021)

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Article Immunology

DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis

Leilei Xia et al.

Summary: The study suggests that DGAT1 expression is associated with the clinical phenotype of ovarian cancer, with poor prognosis in patients with high expression. Inhibiting DGAT1 expression can effectively suppress the proliferation, migration, and invasion of tumor cells, potentially involving in immune processes.

JOURNAL OF IMMUNOLOGY RESEARCH (2021)

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Review Oncology

A Systematic Review of Glioblastoma-Targeted Therapies in Phases II, III, IV Clinical Trials

Elisabete Cruz Da Silva et al.

Summary: This review provides a detailed analysis of targeted therapies for glioblastoma over the last 20 years, covering 257 clinical trials on adults with newly diagnosed or recurrent GBMs in Phases II-IV. Despite current treatment protocols, the survival of patients remains under 18 months, with ongoing clinical studies to explore new therapeutic options. The most frequently studied targets include EGFR, tyrosine kinase receptors, and VEGF/VEGFR, with various other targets and drugs also of interest for potential future therapies.

CANCERS (2021)

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Article Oncology

Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma

Yulong Chen et al.

Summary: This study identified for the first time an association between genetic variations in SOAT1 and the occurrence of HCC, indicating a potential role of SOAT1 in the development of HCC that requires further investigation.

BMC CANCER (2021)

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Article Oncology

LPCAT1 overexpression promotes the progression of hepatocellular carcinoma

Rong-Quan He et al.

Summary: This study revealed that increased LPCAT1 expression correlated with poor prognosis in HCC patients and promoted HCC progression by enhancing cellular growth, migration, and metastasis. The cell cycle and chemical carcinogenesis were identified as the most enriched signaling pathways.

CANCER CELL INTERNATIONAL (2021)

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Review Biochemical Research Methods

Mammalian lipids: structure, synthesis and function

Shamshad Cockcroft

Summary: Lipids play essential roles in cellular membranes by regulating cell signalling and producing bioactive metabolites. Alterations in lipid metabolism are associated with major diseases, including cancer, Type II diabetes, cardiovascular disease, and immune disorders. Understanding the diversity, synthesis, and metabolism of lipids is crucial for comprehending the fundamental functions of cells.

UNDERSTANDING BIOCHEMISTRY 7 (2021)

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Article Biochemistry & Molecular Biology

Lipid Droplet Biosynthesis Impairment through DGAT2 Inhibition Sensitizes MCF7 Breast Cancer Cells to Radiation

Clelia Nistico et al.

Summary: Breast cancer is the most common cancer in women worldwide, and radiotherapy is commonly used to reduce the risk of recurrence after surgery. Research suggests that pre-treatment with the selective DGAT2 inhibitor PF-06424439, combined with X-ray exposure, can enhance the radiosensitivity of breast cancer cells and potentially improve the effectiveness of radiotherapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

Haejin Yoon et al.

Summary: This article discusses the roles of lipids in metabolism, including signal transduction, structural integrity of cellular membranes, energy metabolism, and introduces the latest research advancements and technical methods in lipid metabolism. The authors specifically analyze the effects of specific lipid species in physiological pathways, providing a framework for understanding newly identified targets for regulating lipid homeostasis.

MOLECULAR CELL (2021)

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Article Nanoscience & Nanotechnology

Simultaneous silencing of lysophosphatidylcholine acyltransferases 1-4 by nucleic acid nanoparticles (NANPs) improves radiation response of melanoma cells

Renata F. Saito et al.

Summary: The study found that simultaneously silencing all four LPCAT transcripts using nucleic acid nanoparticles (NANPs) enhanced the therapeutic effects of radiation in melanoma cells by increasing cell death, reducing long-term cell survival, and activating apoptosis, suggesting that NANPs are an effective strategy for improving radiotherapy efficacy in melanomas.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

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Review Pharmacology & Pharmacy

Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

Wei Wu et al.

Summary: Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor with highly infiltrative nature and treatment resistance, highlighting the importance of innovative treatment strategies. The standard treatment for GBM is surgical resection followed by chemoradiotherapy, but the robust DNA repair and self-renewing capabilities of GBM cells lead to resistance against current therapies.

PHARMACOLOGICAL RESEARCH (2021)

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Article Cell Biology

SREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth

Tong-bing Wang et al.

Summary: The inhibitor PF-429242 targeting S1P showed potent inhibition of RCC cell growth both in vitro and in vivo, inducing apoptosis in the cells. Silencing or knockout of S1P had similar inhibitory effects, while overexpression of SREBP1 and S1P enhanced RCC cell proliferation and migration.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma

Mingyue Tao et al.

Summary: This study found that LPCAT1 is highly expressed in ESCC and can reprogram tumor cell cholesterol metabolism, affecting patient prognosis. Knockdown of LPCAT1 significantly inhibits cholesterol synthesis in ESCC cells, leading to reduced cell proliferation, invasion, migration, and tumor growth.

CELL DEATH & DISEASE (2021)

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Article Biology

Lipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance

Luca Tirinato et al.

Summary: The study identified that radioresistant cancer cells in breast, bladder, lung, neuroglioma, and prostate showed an increase in lipid droplet (LD) number, with cells containing higher LDs exhibiting greater clonogenic potential after irradiation. The researchers found a close connection between LD content and iron metabolism, particularly with the presence of the ferritin heavy chain (FTH1). Silencing the FTH1 gene in breast and lung cancer cells reduced LD numbers and increased radiosensitivity, while FTH1 overexpression and iron-chelating treatment restored LD levels and radioresistance.

ELIFE (2021)

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Review Biochemistry & Molecular Biology

Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics Era

Qimin Hai et al.

Summary: The purification and cloning of ACAT and SOAT genes have shed light on their importance in cholesterol metabolism, specifically in foam cell biology and intestinal lipid absorption. While clinical trials using ACAT inhibitors did not show benefits, genetic studies revealed SOAT1 variants are consistently linked to testosterone levels.

METABOLITES (2021)

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Article Oncology

Clinicalpathologic and Prognostic Significance of CGI-58 in Endometrial Cancer

Zhengzheng Shi et al.

Summary: Recent studies have shown that CGI-58 is up-regulated in endometrial cancer, and its high expression is associated with poor histological differentiation and shorter overall survival.

JOURNAL OF CANCER (2021)

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Article Biochemistry & Molecular Biology

ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway

Guohua Chen et al.

Summary: ABHD5 is a coactivator of ATGL that functions as a tumor suppressor by inhibiting cancer cell growth through activating lipolysis leading to downregulation of protein synthesis and inhibition of mTORC1 via the AMPK pathway.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Review Oncology

Tumour fatty acid metabolism in the context of therapy resistance and obesity

Andrew J. Hoy et al.

Summary: This review discusses the mechanistic links between fatty acid metabolism in cancer cells and disease behavior and therapy resistance, emphasizing the importance of factors such as lipid synthesis, storage, and catabolism in supporting tumorigenesis and treatment resistance. The role of membrane fatty acid composition is increasingly appreciated for promoting cell survival and limiting lipotoxicity and ferroptosis, while tumor cells exhibit plasticity in response to metabolic signals, such as obesity and cancer therapeutics, to promote aggressive, treatment-resistant disease. The study also highlights the impact of obesity-associated changes in host fatty acid metabolism on the tumor microenvironment and cancer cell behavior.

NATURE REVIEWS CANCER (2021)

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Review Oncology

Cancer metabolism: looking forward

Inmaculada Martinez-Reyes et al.

Summary: This Perspective discusses the main themes in cancer metabolism research, focusing on the relationship between tumour initiation and progression with metabolic reprogramming, as well as the importance of tumor microenvironment and metabolic regulation.

NATURE REVIEWS CANCER (2021)

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Article Medicine, General & Internal

First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors

Gerald Falchook et al.

Summary: The study aimed to determine the MTD and RP2D of oral FASN inhibitor TVB-2640 and evaluate its safety and efficacy in monotherapy and in combination with paclitaxel. Results showed potent FASN inhibition with manageable toxicity primarily affecting skin and eyes, supporting further investigation particularly in KRASMUT lung, ovarian, and breast cancer patients.

ECLINICALMEDICINE (2021)

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Article Biochemistry & Molecular Biology

Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

Ryan M. Esquejo et al.

Summary: SREBPs are master regulators of the mevalonate pathway and lipid metabolism, and play a crucial role in lipid metabolic disorders. Dipyridamole, a PDE inhibitor, has been shown to limit nuclear accumulation of SREBP by selectively blocking ER-to-Golgi transport of the SCAP-SREBP complex, independent of its PDE inhibitory activity.

CELL CHEMICAL BIOLOGY (2021)

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Article Oncology

LXR alpha activation and Raf inhibition trigger lethal lipotoxicity in liver cancer

Ramona Rudalska et al.

Summary: The research demonstrates that pharmacologically induced lipotoxicity through activation of LXR alpha and inhibition of Raf-1 is an effective metabolic therapeutic strategy for hepatocellular carcinoma. By disrupting fatty acid desaturation and inducing lethal lipotoxicity, therapy resistance in HCC can be overcome.

NATURE CANCER (2021)

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Review Cell Biology

The functional universe of membrane contact sites

William A. Prinz et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Fatostatin inhibits the development of endometrial carcinoma in endometrial carcinoma cells and a xenograft model by targeting lipid metabolism

Lan Yao et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

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Review Cell Biology

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer

Marteinn Thor Snaebjornsson et al.

CELL METABOLISM (2020)

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Review Endocrinology & Metabolism

CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential

Isabel R. Schlaepfer et al.

ENDOCRINOLOGY (2020)

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Article Oncology

A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma

David C. Smith et al.

INVESTIGATIONAL NEW DRUGS (2020)

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Review Cell Biology

Mechanisms and regulation of cholesterol homeostasis

Jie Luo et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Cell Biology

Lipid droplets: platforms with multiple functions in cancer hallmarks

Andre L. S. Cruz et al.

CELL DEATH & DISEASE (2020)

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Article Multidisciplinary Sciences

TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

Cyril Corbet et al.

NATURE COMMUNICATIONS (2020)

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Article Medicine, General & Internal

Lipid Droplets Define a Sub-Population of Breast Cancer Stem Cells

Benjamin J. Hershey et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Pharmacology & Pharmacy

Glioblastoma multiforme: novel therapeutic targets

Matthew Muir et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2020)

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Article Biochemistry & Molecular Biology

New kid on the block: lipid droplets in the nucleus

Antonio D. Barbosa et al.

FEBS JOURNAL (2020)

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Review Biochemistry & Molecular Biology

Lipid droplets throughout the evolutionary tree

Peter K. Lundquist et al.

PROGRESS IN LIPID RESEARCH (2020)

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Article Multidisciplinary Sciences

Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

Chengcheng Guan et al.

NATURE COMMUNICATIONS (2020)

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Article Oncology

Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma

Shiva Kant et al.

MOLECULAR CANCER THERAPEUTICS (2020)

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Article Multidisciplinary Sciences

Structure and mechanism of human diacylglycerol O-acyltransferase 1

Wang Lie et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme

Sui Xuewu et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Structural basis for catalysis and substrate specificity of human ACAT1

Qian Hongwu et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Structure of nevanimibe-bound tetrameric human ACAT1

Long Tao et al.

NATURE (2020)

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Review Endocrinology & Metabolism

CHOLESTEROL REVIEW: A METABOLICALLY IMPORTANT MOLECULE

David S. Schade et al.

ENDOCRINE PRACTICE (2020)

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Article Cell Biology

Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress

Xiang Cheng et al.

CELL METABOLISM (2020)

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Article Immunology

SOAT1 promotes mevalonate pathway dependency in pancreatic cancer

Tobiloba E. Oni et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Developmental Biology

Protein Quality Control and Lipid Droplet Metabolism

Melissa A. Roberts et al.

Annual Review of Cell and Developmental Biology (2020)

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Review Biochemistry & Molecular Biology

The discovery of lipid droplets: A brief history of organelles hidden in plain sight

Rosalind A. Coleman

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2020)

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Review Biochemistry & Molecular Biology

Regulation of lipid droplet homeostasis by hypoxia inducible lipid droplet associated HILPDA

Montserrat A. de la Rosa Rodriguez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2020)

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Article Multidisciplinary Sciences

Lipid Droplets Maintain Energy Homeostasis and Glioblastoma Growth via Autophagic Release of Stored Fatty Acids

Xiaoning Wu et al.

ISCIENCE (2020)

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Article Multidisciplinary Sciences

A metastasis map of human cancer cell lines

Xin Jin et al.

NATURE (2020)

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Review Cell Biology

Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases

Sabina Cisa-Wieczorek et al.

CELLS (2020)

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Review Cell Biology

The dynamic behavior of lipid droplets in the pre-metastatic niche

Chunliang Shang et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells

Colin Rae et al.

ADVANCES IN RADIATION ONCOLOGY (2020)

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Hypoxia, hypoxia-inducible gene 2 (HIG2)/HILPDA, and intracellular lipolysis in cancer

Davide Povero et al.

CANCER LETTERS (2020)

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The interaction between ferroptosis and lipid metabolism in cancer

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SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

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A specific lipid metabolic profile is associated with the epithelial mesenchymal transition program

Anna Maria Giudetti et al.

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Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

Ying Jiang et al.

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What is 'LDL cholesterol'?

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Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

Kamil Soltysik et al.

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DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130

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Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

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SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals

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Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells

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Metabolic regulation of TH17 cells

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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

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Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer

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SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity

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Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance

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Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages

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Phospholipid Remodeling in Physiology and Disease

Bo Wang et al.

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SREBP-2 aggravates breast cancer associated osteolysis by promoting osteoclastogenesis and breast cancer metastasis

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Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer

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Dynamics and functions of lipid droplets

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Astrocytoma progression scoring system based on the WHO 2016 criteria

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An Asymmetry in Monolayer Tension Regulates Lipid Droplet Budding Direction

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The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets

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SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Meta-bolic Targets in Cancer Therapy

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A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes

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Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency

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Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

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Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer

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The carnitine system and cancer metabolic plasticity

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Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact

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Insensitivity to atorvastatin is associated with increased accumulation of intracellular lipid droplets and fatty acid metabolism in breast cancer cells

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The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia

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Retrospective on Cholesterol Homeostasis: The Central Role of Scap

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Role of DGAT enzymes in triacylglycerol metabolism

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Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer

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Ibrutinib Resistance Is Reduced by an Inhibitor of Fatty Acid Oxidation in Primary CLL Lymphocytes

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Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

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Lipid metabolism reprogramming and its potential targets in cancer

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

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Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma

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European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas

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Lipid Droplets in Health and Disease

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LIPIDS IN HEALTH AND DISEASE (2017)

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Applying systems-level spectral imaging and analysis to reveal the organelle interactome

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Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

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Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade

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Blockade of Stearoyl-CoA-desaturase 1 activity reverts resistance to cisplatin in lung cancer stem cells

Maria Elena Pisanu et al.

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Positive regulation of prostate cancer cell growth by lipid droplet forming and processing enzymes DGAT1 and ABHD5

Ranjana Mitra et al.

BMC CANCER (2017)

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Site-1 protease, a novel metabolic target for glioblastoma

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ER Membrane Phospholipids and Surface Tension Control Cellular Lipid Droplet Formation

Kalthoum Ben M'barek et al.

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Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation

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Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets

Can E. Senkal et al.

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Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells

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Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer

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Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection

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PD-L1 expression and prognostic impact in glioblastoma

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Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR

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Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6

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The physics of lipid droplet nucleation, growth and budding

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Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis

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Congenital protein losing enteropathy: an inborn error of lipid metabolism due to DGAT1 mutations

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PML isoform II plays a critical role in nuclear lipid droplet formation

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Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

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Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes

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The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila

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Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

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Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma

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Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells

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SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

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Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth

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Seipin is required for converting nascent to mature lipid droplets

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ELIFE (2016)

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Analysis of SCAP N-glycosylation and Trafficking in Human Cells

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Morphologically and Functionally Distinct Lipid Droplet Subpopulations

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The multifaceted roles of fatty acid synthesis in cancer

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SCAP links glucose to lipid metabolism in cancer cells

Deliang Guo

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Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias

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BLOOD (2015)

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Sugar Makes Fat by Talking to SCAP

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Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

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A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

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Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation

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Cholesterol trafficking and distribution

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ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease

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A conserved family of proteins facilitates nascent lipid droplet budding from the ER

Vineet Choudhary et al.

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K604, a specific acyl-CoA:cholesterol acyltransferase 1 inhibitor, suppresses proliferation of U251-MG glioblastoma Cells

Takuji Ohmoto et al.

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Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

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Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma

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FTIR spectroscopy reveals lipid droplets in drug resistant laryngeal carcinoma cells through detection of increased ester vibrational bands intensity

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ANALYST (2014)

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Glioblastoma: From Molecular Pathology to Targeted Treatment

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ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9 (2014)

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Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

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CELL (2014)

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Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

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CELL METABOLISM (2014)

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Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer

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CURRENT PHARMACEUTICAL DESIGN (2014)

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Rab8a-AS160-MSS4 Regulatory Circuit Controls Lipid Droplet Fusion and Growth

Lizhen Wu et al.

DEVELOPMENTAL CELL (2014)

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Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics

William A. Prinz

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Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis

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Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

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MOLECULAR CANCER THERAPEUTICS (2014)

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Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling

Xiangyan Li et al.

MOLECULAR CANCER THERAPEUTICS (2014)

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Lipid landscapes and pipelines in membrane homeostasis

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A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

Mark R. Gilbert et al.

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Nuclear lipid droplets: A novel nuclear domain

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)

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An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity

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The Somatic Genomic Landscape of Glioblastoma

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CELL (2013)

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Cellular Fatty Acid Metabolism and Cancer

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The Definition of Primary and Secondary Glioblastoma

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Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

Christina A. von Roemeling et al.

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Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

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DEVELOPMENTAL CELL (2013)

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FOXO3 Growth Inhibition of Colonic Cells Is Dependent on Intraepithelial Lipid Droplet Density

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Specific Accumulation of Lipid Droplets in Hepatocyte Nuclei of PFOA-exposed BALB/c Mice

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A clinical review of treatment outcomes in glioblastoma multiforme-the validation in a non-trial population of the results of a randomised Phase III clinical trial: has a more radical approach improved survival?

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BRITISH JOURNAL OF RADIOLOGY (2012)

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Controlling the size of lipid droplets: lipid and protein factors

Hongyuan Yang et al.

CURRENT OPINION IN CELL BIOLOGY (2012)

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Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets

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The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and-2

Jenson Qi et al.

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Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxel

Isabel R. Schlaepfer et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)

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Translation Inhibitors Induce Formation of Cholesterol Ester-Rich Lipid Droplets

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PLOS ONE (2012)

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SREBPs: metabolic integrators in physiology and metabolism

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TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)

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Hallmarks of Cancer: The Next Generation

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Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

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Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia

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Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation

David A. Gross et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

Robert L. Dow et al.

ACS MEDICINAL CHEMISTRY LETTERS (2011)

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An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway

Deliang Guo et al.

CANCER DISCOVERY (2011)

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Lipid droplets: size matters

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JOURNAL OF ELECTRON MICROSCOPY (2011)

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AMPK A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas

Deliang Guo et al.

CELL CYCLE (2010)

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Cholesterol, the central lipid of mammalian cells

Frederick R. Maxfield et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

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Acyl-coenzyme A: cholesterol acyltransferases

Ta-Yuan Chang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)

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The LDL Receptor

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)

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Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases

Gema Perez-Chacon et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2009)

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Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

Henry S. Friedman et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

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The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

Deliang Guo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

Deliang Guo et al.

SCIENCE SIGNALING (2009)

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Quantitative Label-Free Imaging of Lipid Composition and Packing of Individual Cellular Lipid Droplets Using Multiplex CARS Microscopy

Hilde A. Rinia et al.

BIOPHYSICAL JOURNAL (2008)

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Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

Arun Radhakrishnan et al.

CELL METABOLISM (2008)

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Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

Weihua Fei et al.

JOURNAL OF CELL BIOLOGY (2008)

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Cellular cholesterol trafficking and compartmentalization

Elina Ikonen

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

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Membrane lipids: where they are and how they behave

Gerrit van Meer et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

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The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology

Kimberly M. Szymanski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Liver X receptors as integrators of metabolic and inflammatory signaling

N Zelcer et al.

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Protein sensors for membrane sterols

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CELL (2006)

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ATP citrate lyase inhibition can suppress tumor cell growth

G Hatzivassiliou et al.

CANCER CELL (2005)

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

R Stupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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