Journal
BIOMEDICINES
Volume 10, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines10071487
Keywords
liver fibrosis; type 2 diabetes mellitus; NAFLD; fibroscan
Categories
Funding
- Ministry of Science and Technology [MOST 1102314-B-037-056-]
- Kaohsiung Municipal Ta-Tung Hospital [KMTTH-110-R006]
- National Pingtung University of Science and Technology and Kaohsiung Medical University [NPUST kmU-111-P009]
Ask authors/readers for more resources
This study evaluates the determinants of liver fibrosis in T2D patients with NAFLD. The results indicate that aging, obesity, sulfonylurea usage, and high levels of AST increase the risk of liver fibrosis in these patients.
Liver fibrosis is a key pathophysiology process in chronic liver disease. It is still unclear whether the impact of liver fibrosis is not fully realized in type 2 diabetes mellitus (T2D) patients with nonalcoholic fatty liver disease (NAFLD), and the factors affecting nonalcoholic steatohepatitis (NASH) or liver stiffness also remain unclear. The aim of this study was to evaluate the determinants of liver fibrosis and in T2D patients with NAFLD. Liver fibrosis and steatosis were measured using transient elastography (FibroScan). Of 226 T2D patients with NAFLD, 50 with liver fibrosis had higher body mass index, serum uric acid, triglyceride and glycated hemoglobin levels and lower high density lipoprotein levels than 176 without liver fibrosis. Multivariate analysis revealed that aging, obesity, sulfonylurea usage and high levels of AST increased the risk of liver fibrosis in T2D patients with NAFLD. Our findings provide useful information to clinical physicians for earlier detection of liver fibrosis in T2D patients with NAFLD and to prevent liver fibrosis through controlling these risk factors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available